Table 1 Characteristics of study participants

Total, n (% males)

Cohort 1 (born 1982–1985), n (%)

Cohort 2 (born 1991–1992), n (%)

Cohort 3 (born 1999–2000), n (%)

63 (43%)

23 (37%)

19 (30%)

21 (33%)

64 (44%)

26 (41%)

18 (28%)

20 (31%)

GA (weeks), mean (SD)

27 (2)

Term-born

Birthweight (grams), mean (SD)

945 (217)

3527 (324)

< 0.001^a

Small for gestational age, n (%)

16 (25%)

Extremely preterm GA < 28 weeks, n (%)

39 (62%)

Extremely low birthweight < 1000 g, n (%)

37 (59%)

Moderate/severe BPD, n (%)

21 (33%)

Days on ventilator, mean (SD)

8 (9)

Days on CPAP, mean (SD)

33 (14)

Days on O₂-supplement, mean (SD)

52 (35)

Pre-natal steroid treatment, n (%)

35 (55%)

Post-natal steroid treatment, n (%)

14 (22%)

Surfactant, n (%)

28 (44%)

Age (years), mean (SD)

27 (6)

28 (7)

0.95^b

Height (cm), mean (95% CI)

168 (167, 170)

174 (172, 175)

< 0.001^c

Weight (kg), mean (95% CI)

68 (64, 72)

75 (71, 79)

0.01^c

Smokers, n (%)

4 (6%)

4 (6%)

1.00^b

BMI (kg/m²), mean (SD)

BSA (m²), mean (95% CI)

24.0 (4.1)

1.8 (1.7, 1.8)

24.9 (6.0)

1.9 (1.8, 1.9)

0.75^b

< 0.001^c

Systolic BP (mmHg), mean (SD)

113 (12)

112 (10)

0.87^b

Diastolic BP (mmHg), mean (SD)

71 (8)

70 (8)

0.98^b

Heartrate (beats /minute), mean (SD)

69 (14)

65 (11)

0.13^a