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Table 2 Blood lipid levels and lipid-lowering strategies of the sister

From: Different clinical phenotypes of a pair of siblings with familial hypercholesterolemia: a case report and literature review

Date

TC

LDL-C

Lp(a)

Lipid-lowering strategies

Notes

6-24-2020

14.31

11.85

 

evolocumab 420 mg SC

baseline levels without any medication

6-30-2020

11.66 (−18.5%)

9.76 (−17.6%)

112

 

6 days after evolocumab 420 mg

7-7-2020

11.5 (−19.6%)

9.71 (−18.1%)

  

13 days after evolocumab 420 mg

7-14-2020

11.87 (−17.0%)

11.27 (−4.9%)

 

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

20 days after evolocumab 420 mg

7-29-2020

7 (−51.1%)

4.65 (−60.8%)

136.6 (+ 22.0%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

 

8-22-2020

5.62 (−60.8%)

3.67 (−69.0%)

113.3 (+ 1.2%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

 

9-12-2020

   

evolocumab 140 mg SC

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

 

10-12-2020

6.6 (−53.9%)

4.39 (−63.0%)

95.7 (−14.6%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

 

10-14-2020

   

evolocumab 140 mg SC

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

probucol 0.5 g bid

 

10-24-2020

4.94 (−65.5%)

3.15 (−73.4%)

90.5 (−19.2%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

probucol 0.5 g bid

10 days after evolocumab 140 mg

10-28-2020

   

evolocumab 140 mg SC

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

probucol 0.5 g bid

 

11-28-2020

5.46 (−61.8%)

3.85 (−67.5%)

90.2 (−34%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

probucol 0.5 g bid

 

3-13-2021

6.28 (−56.1%)

4.56 (−61.5%)

89.4 (−20.2%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

probucol 0.5 g bid

 

4-17-2021

6.36 (−55.6%)

4.46 (−62.4%)

93 (−17.0%)

rosuvastatin 20 mg qd

ezetimibe 10 mg qd

probucol 0.5 g bid

 
  1. The levels and percent of change from baseline are expressed as mmol/L (%) for TC and LDL-C and mg/dL (%) for Lp(a)
  2. TC Total cholesterol, LDL-C Low density lipoprotein cholesterol, Lp(a) Lipoprotein (a), LA Lipoprotein apheresis, qd Once a day, bid Twice a day, SC Subcutaneous