Skip to main content
Fig. 1 | BMC Cardiovascular Disorders

Fig. 1

From: The mechanism by which miR-494-3p regulates PGC1-α-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia—reperfusion injury

Fig. 1

Mitochondrial autophagy and differential expression of miR-494-3p and PGC1-α were observed in H/R cardiomyocytes

(A) The expression of miR-494-3p was detected by RT‒qPCR. (B) The expression of PGC1-α was detected by Western blotting. (C) The expression of the autophagy-related proteins LC3 and Beclin 1 was detected by Western blotting. (D) The expression of PINK1 and Parkin was detected by Western blotting. (E) The expression of Mfn1, Mfn2 and OPA1 was detected by Western blotting. (F) Changes in ΔΨm were detected by JC-1 staining. *P < 0.05, **P < 0.01, *P < 0.001, ****P < 0.0001 vs. control. n = 3, all experiments were repeated three times.

Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us