From: AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients
Characteristics | < 40 years old (n = 20) | 41–50 years old (n = 178) | 51–60 years old (n = 218) | > 60 years old (n = 293) | P Value |
---|---|---|---|---|---|
Gender, n (%) | Â | Â | Â | Â | Â |
Male | 18(90.0%) | 139(77.7%) | 123(56.2%) | 127(42.8%) | < 0.001 |
Female | 2(10.0%) | 40(22.3%) | 96(43.8%) | 170(57.2%) | |
Smoking, n (%) | Â | Â | Â | Â | Â |
No | 7(35.0%) | 83(46.4%) | 146(66.7%) | 235(79.1%) | < 0.001 |
Yes | 13(65.0%) | 96(53.6%) | 73(33.3%) | 62(20.9%) | |
Alcohol intake, n (%) | Â | Â | Â | Â | |
No | 9(1.7%) | 104(19.5%) | 164(30.8%) | 256(48.0%) | < 0.001 |
Yes | 11(55.0%) | 75(41.9%) | 55(25.1%) | 41(13.8%) | |
T2DM | Â | Â | Â | Â | Â |
No | 17(85.0%) | 155(86.6%) | 171(78.1%) | 207(69.7%) | < 0.001 |
Yes | 3(15.0%) | 24(13.4%) | 48(21.9%) | 90(30.3%) | |
CAD | Â | Â | Â | Â | Â |
No | 15(75.0%) | 101(56.4%) | 107(48.9%) | 118(39.7%) | < 0.001 |
Yes | 5(25.0%) | 78(43.6%) | 112(51.1%) | 179(60.3%) | |
SBP (mmHg) | 137 ± 16 | 129 ± 17 | 129 ± 16 | 132 ± 20 | 0.039 |
DBP (mmHg) | 87 ± 14 | 82 ± 12 | 80 ± 11 | 77 ± 13 | < 0.001 |
BMI (kg/m2) | 29.34 ± 3.52 | 27.03 ± 2.91 | 26.60 ± 3.61 | 25.63 ± 3.34 | < 0.001 |
Glucose(mmol/L) | 6.16 ± 2.06 | 7.06 ± 3.27 | 6.30 ± 2.63 | 7.76 ± 3.58 | < 0.001 |
TG (mmol/L) | 2.68 ± 3.04 | 2.36 ± 1.84 | 2.00 ± 1.73 | 1.84 ± 1.20 | 0.004 |
TC (mmol/L) | 4.72 ± 1.17 | 4.37 ± 1.07 | 4.31 ± 1.15 | 4.26 ± 1.11 | 0.311 |
HDL–c (mmol/L) | 1.02 ± 0.25 | 0.96 ± 0.23 | 1.04 ± 0.31 | 1.08 ± 0.30 | 0.001 |
LDL–c (mmol/L) | 3.12 ± 0.79 | 2.74 ± 0.90 | 2.68 ± 0.87 | 2.62 ± 0.93 | 0.096 |
MACCEs, n (%) | 1 (0.9%) | 15 (12.8%) | 37 (31.6%) | 64 (54.7%) | 0.001 |
RS389566 TT, n (%) | 13 (2.8%) | 116 (25.1%) | 133 (28.7%) | 201 (43.4%) | 0.446 |
RS16860760 AA + AG, GG n (%) | 20 (2.8%) | 179 (25%) | 219 (30.6%) | 297 (41.5%) | 0.932 |