Table 1 Comparison of baseline characteristics stratified by the primary endpoint
Variable | ALL (4946) | Non-MACCEs (4712) | MACCEs (234) | P value |
|---|---|---|---|---|
Age,years | 62 (55–71) | 62 (54–70) | 65 (58–74) | 0.001 |
Male, n (%) | 3182 (64.3) | 3021(64.1) | 161(68.8) | 0.144 |
Hypertension,n (%) | 3415 (69.0) | 3249 (69.0) | 166 (70.9) | 0.521 |
DM,n (%) | 1532 (31.0) | 1451 (30.8) | 81 (34.6) | 0.217 |
Family history of CAD, n (%) | 693(14.0) | 663(14.1) | 30(12.8) | 0.591 |
Smoking,n (%) | 1223 (24.7) | 1175 (24.9) | 48 (20.5) | 0.126 |
SBP,mmHg | 129 (120–140) | 129 (120–140) | 129 (120–140) | 0.713 |
DBP,mmHg | 78 (70–84) | 78 (70–84) | 78 (70–83) | 0.756 |
BMI, kg/m2 | 25.71 (23.49–28.4) | 25.71 (23.44–28.41) | 25.61 (23.71–28.09) | 0.739 |
Creatinine,µmol/L | 69.0 (58.97–80.00) | 59 (58.6–79.68) | 71 (62–84.76) | 0.004 |
UA, mg/dL | 320 (266–376.21) | 320 (266–376) | 325 (267–382.24) | 0.268 |
eGFR, mL/min/1.73 m2 | 91.28 (69.45–117.50) | 91.84 (70.02–118.08) | 83.702 (62.8–109.23) | 0.001 |
FBG, mmol/L | 5.37 (4.75–6.82) | 5.35 (4.75–6.78) | 5.54 (4.82–7.64) | 0.024 |
TG, mmol/L | 1.62 (1.13–2.43) | 1.62 (1.13–2.44) | 1.47 (1.07–2.23) | 0.037 |
TC, mmol/L | 4.18 (3.52–4.88) | 4.18 (3.52–4.87) | 4.20(3.35–4.98) | 0.657 |
HDL-C, mmol/L | 1.11 (0.93–1.32) | 1.11 (0.93–1.33) | 1.05 (0.87–1.26) | 0.002 |
LDL-C, mmol/L | 2.72 (2.12–3.33) | 2.72(2.13–3.32) | 2.74 (2.07–3.50) | 0.466 |
Total protein, g/L | 67.7 (64.3–72.00) | 67.7 (64.3–72.00) | 67.45 (63.8–71.9) | 0.71 |
Albumin,g/L | 41.2(38.64–43.70) | 41.2(38.7–43.73) | 40.55(37.50–43.10) | 0.001 |
Fibrinogen, g/L | 3.27(2.82–3.69) | 3.26 (2.81–3.68) | 3.37 (3.03–3.83) | 0.001 |
FAR | 0.0787(0.0671–0.0913) | 0.0785 (0.0669–0.0909) | 0.0833 (0.0727–0.0974) | 0.001 |
CACS | 75.55(18.20–259.73) | 73.20 (17.5–253.3) | 156.40 (39.2–498.1) | 0.001 |
Medication | ||||
 Aspirin, n (%) | 2365(47.8) | 2260(48.0) | 105(44.9) | 0.356 |
 β-blocker, n (%) | 1528(30.9) | 1465(31.1) | 63 (26.9) | 0.178 |
 ACEI/ARB, n (%) | 1357(27.4) | 1317(27.9) | 40(17.1) | 0.001 |
 Statins, n (%) | 2639(53.4) | 2525(53.6) | 114 (48.7) | 0.145 |
 CCB, n (%) | 1305 (26.4) | 1268 (26.9) | 37(15.8) | 0.001 |