Table 1 Overview antihypertensive drugs included in the RHYME-RCT trial
Antihypertensive drug [metabolite] | Minimal drug dose for inclusion (mg) | LLOD (μg/L) [25] |
|---|---|---|
Amlodipine | 5 | 17.1 |
Barnidipine | 10 | 2.1 |
Bumetanide | 1 | 4.0 |
Doxazosin | 4 | 18.1 |
Enalapril | 20 | 0.4 |
[Enalaprilat] | – | 1.1 |
Hydrochlorothiazide | 12.5 | 40.2 |
Irbesartan | 150 | 7.7 |
Losartan | 50 | 1.7 |
[Losartan-CA] | – | 2.6 |
Metoprolol | 50 CR or 25Â mg two times daily (normal release) | 0 |
Nifedipine | 30 | 3.5 |
Perindopril | 4 | 0.7 |
[Perindoprilat] | – | 1.3 |
Spironolactone | 12.5 | 5.2 |
[Canrenone] | – | 26.8 |
Valsartan | 80 | 21.3 |