The association among uric acid, microalbumin and estimated glomerular filtration rate in hypertensive patients: a case control study

Table 6 The multivariate logistic regression analysis for increased 24 h-MAU and mildly decrease eGFR in subgroup analysis

Model*	Variates	Increased 24 h-MAU				Variates	Mildly decrease eGFR
Model*	Variates	B	SE	P	OR (95%CI)	Variates	B	SE	P	OR (95%CI)
1 (male)	UA (every increased 10 μmol/L)	0.033	0.016	0.033	1.034 (1.003–1.065)	Fasting glucose	0.785	0.219	< 0.001	2.193 (1.428–3.369)
	BMI	0.090	0.037	0.014	1.094 (1.018–1.175)	Diuretic intake	1.008	0.469	0.031	2.741 (1.094–6.868)
	Duration of hypertension			0.001
	Less than 1 year	Reference
	1–5 years	0.112	0.331	0.735	1.118 (0.585–2.138)
	5–10 years	1.075	0.396	0.007	2.930 (1.349–6.363)
	More than 10 years	1.170	0.394	0.003	3.223 (1.490–6.975)
	Grade 3 hypertension	1.328	0.310	< 0.001	3.772 (2.056–6.923)
1 (female)	UA (every increased 10 μmol/L)	0.081	0.036	0.023	1.084 (1.011–1.163)	Increased 24 h-MAU	2.238	1.255	0.075	9.375 (0.801–109.775)
1 (female)	ACEI/ARB intake	− 1.432	0.613	0.019	0.239 (0.072–0.793)
2 (male)	Hyperuricemia	1.336	0.309	< 0.001	1.821 (1.078–3.076)	Fasting glucose	0.785	0.219	< 0.001	2.193 (1.428–3.369)
	BMI	0.093	0.036	0.010	1.098 (1.023–1.178)	Diuretic intake	1.008	0.469	0.031	2.741 (1.094–6.868)
	Duration of hypertension			0.002
	Less than 1 year	Reference
	1–5 years	0.067	0.329	0.839	1.069 (0.561–2.035)
	5–10 years	1.042	0.393	0.008	2.834 (1.311–6.125)
	More than 10 years	1.141	0.392	0.004	3.130 (1.451–6.751)
	Grade 3 hypertension	1.336	0.309	< 0.001	3.803 (2.074–6.974)
2 (female)	Hyperuricemia	1.319	0.641	0.039	3.741 (1.066–13.127)	Increased 24 h-MAU	2.238	1.255	0.075	9.375 (0.801–109.775)
2 (female)	ACEI/ARB intake	− 1.340	0.605	0.027	0.262 (0.080–0.857)

*Model 1: included UA (every increased 10 μmol/L) as argument. Model 2: included hyperuricemia as argument. Multivariate analysis was adjusted for age, BMI, duration of hypertension, grade of hypertension, ACEI/ARB intake, β-blocker intake, CCB intake, diuretic intake, fasting glucose, 2-h glucose, 24 h mean SBP, 24 h mean DBP, increased 24 h-MAU/mildly decreased eGFR and UA.
24 h-MAU: 24-h microalbuminuria; increased 24 h-MAU: 24 h-MAU ≥ 30 mg/24 h; eGFR: estimated glomerular filtration rate; mildly decreased eGFR: eGFR < 90 ml ·min⁻¹ ·1.73 m⁻²; UA: uric acid; BMI: body mass index; ACEI/ARB: angiotensin-converting enzyme inhibitor/angiotensin receptor inhibitor

ISSN: 1471-2261