Table 4 The mediating effect of increased 24 h-MAU on the relationship between UA and mildly decreased eGFR

Equation	Independent variable	Dependent variable	B	SE	P	OR(95%CI)	Z_a × Z_b	Asymmetric 95% CI_Za×Zb	Mediating effect (%)
Model 1*
1)c	UA (every increased 10 μmol/L)	Mildly decreased eGFR	0.054	0.014	< 0.001	1.055 (1.028–1.084)	16.037	0.015–0.079	25.0
2)a	UA (every increased 10 μmol/L)	Increased 24 h-MAU	0.045	0.009	< 0.001	1.046 (1.028–1.064)
3)b	Increased 24 h-MAU	Mildly decreased eGFR	0.959	0.299	0.001	2.609 (1.453–4.683)
c’	UA (every increased 10 μmol/L)		0.040	0.014	0.005	1.041 (1.012–1.070)
Model 2*
1)c	Hyperuricemia	Mildly decreased eGFR	0.865	0.278	0.002	2.374 (1.376–4.095)	14.115	0.170–1.162	20.1
2)a	Hyperuricemia	Increased 24 h-MAU	0.693	0.172	< 0.001	2.000 (1.427–2.803)
3)b	Increased 24 h-MAU	Mildly decreased eGFR	1.030	0.294	< 0.001	2.800 (1.574–4.980)
c’	Hyperuricemia		0.691	0.294	0.019	1.996 (1.121–3.552)

*Model 1: included UA (every increased 10 μmol/L) as argument. Model 2: included hyperuricemia as argument. 24 h-MAU: 24-h microalbuminuria; increased 24 h-MAU: 24 h-MAU ≥ 30 mg/24 h; eGFR: estimated glomerular filtration rate; mildly decreased eGFR: eGFR < 90 ml·min⁻¹·1.73 m⁻²

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