Table 3 Genotypic and allelic distribution of the P2Y1 and P2Y12 gene between AMI and contrast groups
SNP | Genetic model | Genotype/allele | Controls (n = 194) | AMI (n = 189) | Odds ratio (95% CI) | P value |
|---|---|---|---|---|---|---|
P2Y1 c.1622A > G | Codominant | AA vs. AG vs. GG | 106 (54.6%)/68 (35.1%)/20 (10.3%) | 102 (54.0%)/73 (38.6%)/14 (7.4%) | – | 0.536 |
|  | Allele contrast | A vs. G | 280 (72.2%)/108 (27.8%) | 277 (73.3%)/101 (26.7%) | 0.945 (0.688 ~ 1.299) | 0.729 |
|  | Dominant | AA vs. AG + GG | 106 (54.6%)/88 (45.4%) | 102 (54.0%)/87 (45.0%) | 1.027 (0.687 ~ 1.536) | 0.895 |
|  | Recessive | AA + AG vs.GG | 174 (89.7%)/20 (10.3%) | 175 (92.6%)/14 (7.4%) | 0.696 (0.341 ~ 1.422) | 0.318 |
|  | Over-dominant | AA + GG vs. AG | 126 (64.9)/68 (35.1%) | 116 (61.4%)/73 (38.6%) | 1.166 (0.770 ~ 1.767) | 0.469 |
P2Y12 i-744 T > C# | Codominant | TT vs. TC vs. CC | 163 (84.0%)/28 (14.4%)/3 (1.5%) | 135 (71.4%)/50 (26.5%)/4 (2.1%) | – | 0.008* |
|  | Allele contrast | T vs. C | 354 (91.2%)/34 (8.8%) | 320 (84.7%)/58 (15.3%) | 1.887 (1.204 ~ 2.958) | 0.005* |
|  | Dominant | TT vs. TC + CC | 163 (84.0%)/31 (15.9%) | 135 (71.4%)/54 (28.6%) | 2.103 (1.279 ~ 3.457) | 0.003* |
|  | Recessive | TT + TC vs. CC | 191 (98.5%)/3 (1.5%) | 180 (97.9%)/4 (2.1%) | 1.415 (0.312 ~ 6.409) | 0.718 |
|  | Over-dominant | TT + CC vs. TC | 166 (85.5%)/28 (14.4%) | 139 (73.5%)/50 (26.5%) | 2.133 (1.275 ~ 3.568) | 0.003* |
P2Y12 c.34C > T | Codominant | CC vs. CT vs. TT | 124 (63.9%)/60 (30.9%)/10 (5.2%) | 110 (58.2%)/71 (37.6%)/8 (4.2%) | – | 0.383 |
|  | Allele contrast | C vs. T | 308 (79.4%)/80 (20.6%) | 291 (77.0%)/87 (23.1%) | 1.151 (0.817 ~ 1.622) | 0.442 |
|  | Dominant | CC vs. CT + TT | 124 (63.9%)/70 (36.1%) | 110 (58.2%)/79 (41.8%) | 1.272 (0.843 ~ 1.920) | 0.251 |
|  | Recessive | CC + CT vs. TT | 184 (94.8%)/10 (5.2%) | 181 (95.8%)/8 (4.2%) | 0.813 (0.314 ~ 2.107) | 0.670 |
|  | Over-dominant | CC + TT vs. CT | 134 (69.1%)/60 (30.9%) | 118 (62.4%)/71 (37.6%) | 1.344 (0.880 ~ 2.052) | 0.171 |