Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation

Table 2 The genotype distribution of the Hardy–Weinberg equilibrium in the two groups

SNP	Controls (n = 194)			P value	AMI (n = 189)			P value
SNP	Genotype (Observed value/Expected value)			P value	Genotype (Observed value/Expected value)			P value
P2Y1 c.1622A > G	AA (106/101.0)	AG (68/77.9)	GG (20/15.0)	0.0757	AA (102/101.5)	AG (73/74.0)	GG (14/13.5)	0.8507
P2Y12 c.34C > T	CC (124/122.2)	CT (60/63.5)	TT (10/8.2)	0.4421	CC (110/112.0)	CT (71/67.0)	TT (8/10.0)	0.4089
P2Y12 i-744 T > C^#	TT (163/161.5)	TC (28/31.0)	CC (3/1.5)	0.1750	TT (135/135.4)	TC (50/49.1)	CC (4/1.4)	0.8012

AMI acute myocardial infarction, SNP single nucleotide polymorphism
^#i-744 T > C genotype was used to tag the H1/H2 haplotype. TT, TC, and TT genotypes referred to H1/H1, H1/H2, and H2/H2 haplotypes, respectively

ISSN: 1471-2261