Table 1 Body mass, blood pressure, circulating inflammatory marker concentrations and echocardiographic measures of diastolic function

n

26

28

16

Female n (%)

12 (46)

15 (54)

8 (50)

Body mass at baseline (g)

393.7 ± 8.8

380.6 ± 8.0

382.5 ± 11.3

Body mass at termination (g)

451.7 ± 8.8

420.5 ± 8.0

400.0 ± 11.3*

SBP (mm Hg)

DBP (mm Hg)

128 ± 2

87 ± 2

130 ± 2

88 ± 1

132 ± 2

86 ± 2

Circulating inflammatory marker concentrations

TNF-α (pg/ml)

91.2 ± 5.0

159.9 ± 7.0*

(1.75 fold)^a

146.2 ± 9.6*

(1.59 fold)

IL-6 (pg/ml)

16.0 ± 1.8

31.1 ± 2.0*

(1.94 fold)

27.9 ± 2.6*

(1.75 fold)

CRP (ng/ml)

0.09 ± 0.03

0.58 ± 0.04*

(6.4 fold)

0.43 ± 0.05*^#

(4.8 fold)

Left ventricular diastolic function measures

e′ (cm/s)

4.52 ± 0.11

3.60 ± 0.09*

3.50 ± 0.11*

e′/a′

1.44 ± 0.06

1.27 ± 0.07*

1.04 ± 0.04*

E/e′

25.12 ± 1.25

31.61 ± 1.34*

32.52 ± 1.55*