Fig. 6

ROCK2 overexpression overturned miR-942-5p-mediated functions in cell viability, proliferation, apoptosis, angiogenesis, and inflammatory response. HUVECs were treated with Control, ox-LDL, ox-LDL + miR-NC, ox-LDL + miR-942-5p, ox-LDL + miR-942-5p + pcDNA, or ox-LDL + miR-942-5p + ROCK2. A Western blot analysis of ROCK2 in treated HUVECs. B–G Cell viability, apoptosis, tube formation, protein expression levels, and inflammatory factors in treated HUVECs were analyzed by MTT, flow cytometry, tube formation, western blot, and ELISA assays. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. All cellular experiments were independently repeated three times. One-way ANOVA was utilized to analyze the differences in (A, B, D, and E), while two-way ANOVA was utilized to assess the differences in (C, F, and G)