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Table 4 Association between single nucleotide polymorphisms and ischemic events and bleeding in all subjects

From: The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation

Gene

SNP

Mod

Stroke/SEE

Any Bleeding

Major bleeding

Minor bleeding

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

ABCB1

rs4148738

Add

1.52 (0.62, 3.70)

0.359

2.29 (1.05, 5.01)

0.038*

3.29 (1.02, 10.59)

0.046*

1.59 (0.73, 3.44)

0.240

Dom

1.50 (0.63, 3.60)

0.360

2.30 (1.06, 4.96)

0.035*

8.17 (1.10, 60.88)

0.040*

1.61 (0.74, 3.49)

0.225

Rec

1.65 (0.65, 4.15)

0.290

2.19 (1.00, 4.76)

0.048*

2.55 (0.93, 7.03)

0.070

1.56 (0.71, 3.42)

0.266

rs1045642

Add

1.45 (0.60, 3.49)

0.404

2.31 (1.06, 5.03)

0.034*

3.34 (1.04, 10.74)

0.043*

1.61 (0.74, 3.50)

0.230

Dom

1.47 (0.61, 3.52)

0.388

2.27 (1.06, 4.87)

0.034*

7.77 (1.03, 58.39)

0.046*

1.62 (0.74, 3.49)

0.225

Rec

1.52 (0.62, 3.74)

0.362

2.20 (1.00, 4.82)

0.049*

2.50 (0.89, 7.00)

0.083

1.57 (0.72, 3.46)

0.260

CES1

rs2244613

Add

1.55 (0.63, 3.79)

0.339

2.30 (1.05, 5.04)

0.038*

2.62 (0.95, 7.21)

0.062

1.61 (0.74, 3.50)

0.225

Dom

1.50 (0.63, 3.60)

0.360

2.28 (1.04, 5.00)

0.038*

2.61 (0.94, 7.24)

0.066

1.62 (0.74, 3.51)

0.227

Rec

1.54 (0.63, 3.77)

0.342

2.33 (1.06, 5.14)

0.035*

2.67 (0.97, 7.33)

0.058

1.63 (0.75, 3.55)

0.216

rs8192935

Add

1.67 (0.65, 4.29)

0.290

2.26 (1.03, 4.96)

0.042*

2.50 (0.88, 7.05)

0.084

1.61 (0.74, 3.53)

0.232

Dom

1.67 (0.65, 4.31)

0.290

2.31 (1.04, 5.10)

0.039*

2.39 (0.83, 6.83)

0.105

1.67 (0.75, 3.74)

0.209

Rec

1.54 (0.63, 3.75)

0.348

2.42 (1.08, 5.42)

0.031*

2.65 (0.96, 7.34)

0.060

1.72 (0.77, 3.79)

0.180

  1. OR: odds ratio; 95%CI: 95% confidence interval; SEE: systemic embolic events; ADD: additive model; DOM: dominant model; REC: recessive model; additive model: comparing the minor allele with major allele subjects; dominant model: comparing carriers of the minor allele with the major homozygous subjects; recessive model: comparing carriers of the major allele with the minor homozygous subjects
  2. *P<0.05