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Table 1 Outcomes assessed in the VascuFit study

From: VascuFit: vascular effects of non-linear periodized exercise training in sedentary adults with elevated cardiovascular risk – protocol for a randomized controlled trial

Outcome measure

Data collection instrument

Telephone interview

Baseline appointment (T0)

Fitness check (T1)

Final appointment (T2)

Inclusion criteria a

Questionnaire (5 items)

x

   

Exclusion criteria a

Questionnaire (8 items)

x

   

Physical activity readiness

PAR_Q (7 items)

 

x

  

Physical activity

PA_Q (41 items)

 

x

  

General well-being

POMS (19 items)

 

x

 

x

General health

Medical interview b, physical examination

 

x

 

x

Body composition

BMI, bioelectrical impedance analysis

 

x

 

x

Cardiovascular function

BP, heart rate, ECG at rest and during exercise

 

x

x

x

Macrovascular endothelial function

baFMD

 

x

 

x

Microvascular endothelial function

SVA

 

x

 

x

Molecular endothelial function

endomiRs (15 species)

 

x

 

x

Cellular endothelial function

ECs, EPCs

 

x

 

x

Circulating cardiovascular risk factors

fasting blood glucose, LDL-, HDL- and total cholesterol, triglycerides, hs-CRP, sphingolipidome

 

x

 

x

Pulmonary function

Spirometry

 

x

 

x

Cardiorespiratory fitness

Spiroergometry with breath-by-breath gas analysis and capillary blood lactate

 

x

x

x

  1. a See methods section for details, b Medical interview including general health, chronic diseases, lifestyle and family history of cardiovascular diseases (14 items) and current medication (2 items per drug)
  2. Abbreviations: baFMD Brachial-arterial flow-mediated dilation, BMI Body mass index, BP Blood pressure, ECG Electrocardiography, ECs Mature endothelial cells, endomiRs Set of microRNAs regulating key molecular pathways of endothelial cell function, EPCs Endothelial progenitor cells, HDL-cholesterol High-density lipoprotein cholesterol, hs-CRP High-sensitivity C-reactive protein, LDL-cholesterol Low-density lipoprotein cholesterol, PA_Q Physical activity questionnaire, PAR_Q Physical activity readiness questionnaire, POMS Profile of mood states questionnaire, SVA Static retinal vessel analysis