Fig. 1

Differentially expressed genes in MI compared to sham controls. A UMAP plot was used to visualize the relationships between samples, purple dots represent the MI samples and the green dots represent the sham control samples. B Volcano plot of p values as a function of the weighted fold change for genes in MI and sham control samples. gray dots represent genes that are not significantly differentially expressed (log(fold change) < −1 or > 1, p > 0.05), red dots represented the gens that are significantly upregulated in MI situation (log(fold change) > 1, p < 0.05), the baby blue dots represent the genes that are significantly downregulated in MI samples (log(fold change) < −1, p < 0.05). C Heatmap shows the expression profiles for the 235 differentially expressed genes (102 downregulated and 133 upregulated). The red to green color gradient indicates a high to low level of expression. For A to C, n = 6 samples in each group