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Table 5 Medication-related subgroup analysis for association between blood albumin level with risk of CV complications and 1-year mortality risk

From: The association between blood albumin level and cardiovascular complications and mortality risk in ICU patients with CKD

Variables

Medications

CV complications

1-year mortality

OR (95% CI)

P value

P*

OR (95% CI)

P value

P*

Albumin-1st

Albumin

1.242 (0.718, 2.150)

0.439

0.064

1.143 (0.678, 1.928)

0.615

0.009

 

NO Albumin

2.131 (1.605, 2.829)

 < 0.001

0.557 (0.422, 0.734)

 < 0.001

 

βRB

2.173 (1.577, 2.994)

 < 0.001

0.142

0.737 (0.545, 0.997)

0.048

0.193

 

NO βRB

1.576 (1.055, 2.354)

0.026

0.520 (0.343, 0.788)

0.002

 

Statins

2.417 (1.439, 4.059)

 < 0.001

0.250

0.573 (0.341, 0.966)

0.036

0.500

 

NO statins

1.675 (1.256, 2.233)

 < 0.001

0.706 (0.536, 0.930)

0.013

 

Heparin

1.670 (1.213, 2.301)

0.002

0.239

0.732 (0.533, 1.004)

0.053

0.286

 

NO Heparin

2.294 (1.538, 3.421)

 < 0.001

0.578 (0.398, 0.840)

0.004

Albumin-max

Albumin

0.957 (0.582, 1.572)

0.861

0.025

1.289 (0.805, 2.065)

0.290

0.006

 

NO Albumin

1.847 (1.383, 2.467)

 < 0.001

0.628 (0.473, 0.834)

0.001

 

βRB

1.687 (1.228, 2.316)

0.001

0.271

0.852 (0.627, 1.157)

0.304

0.418

 

NO βRB

1.393 (0.937, 2.070)

0.102

0.687 (0.462, 1.022)

0.064

 

Statins

1.970 (1.171, 3.313)

0.011

0.173

0.547 (0.318, 0.943)

0.030

0.123

 

NO statins

1.383 (1.043, 1.835)

0.025

0.877 (0.668, 1.150)

0.341

 

Heparin

1.393 (1.023, 1.896)

0.035

0.447

0.825 (0.607, 1.122)

0.220

0.73

 

NO Heparin

1.782 (1.188, 2.671)

0.005

0.768 (0.522, 1.130)

0.181

Albumin-min

Albumin

1.140 (0.647, 2.007)

0.650

0.025

0.859 (0.499, 1.481)

0.585

0.032

 

NO Albumin

2.139 (1.619, 2.825)

 < 0.001

0.508 (0.385, 0.669)

 < 0.001

 

βRB

2.157 (1.570, 2.962)

 < 0.001

0.162

0.651 (0.480, 0.884)

0.006

0.156

 

NO βRB

1.607 (1.083, 2.386)

0.019

0.458 (0.304, 0.691)

 < 0.001

 

Statins

2.165 (1.327, 3.531)

0.002

0.510

0.419 (0.247, 0.712)

0.001

0.197

 

NO statins

1.704 (1.277, 2.273)

 < 0.001

0.655 (0.497, 0.864)

0.003

 

Heparin

1.737 (1.247, 2.421)

0.001

0.435

0.563 (0.402, 0.788)

 < 0.001

0.991

 

NO Heparin

2.085 (1.440, 3.018)

 < 0.001

0.592 (0.418, 0.840)

0.003

  1. Adjusted for age, gender, insurance, ethnicity, hypertension, diabetes and malignant tumor
  2. P* for interaction in two subgroup
  3. CV: cardiovascular; ICU: intensive care unit; CKD: chronic kidney disease