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Table 3 Distributions of the eNOS3 864G/T and IL-1β 315C/T alleles and genotypes in the CSFP and control groups

From: Endothelial nitric oxide synthase Asp298Glu (894G/T) gene polymorphism as a possible risk factor for the coronary slow flow phenomenon among Iranians

 

Patients With CSFP; N (%)

Controls; N (%)

OR (95% CI)b

P valuea

eNOS 894G/T

    

Allele Frequency

    

 G

287 (80)

124 (71)

1.00

0.03

 T

73 (20)

50 (29)

1.58 (1.04–2.42)

 

 Total

360 (100)

174 (100)

  

Genotypes (codominant)

    

 G/G

117 (65)

45 (51.7)

1.00

0.11

 G/T

53 (29.4)

34 (39.1)

0.60 (0.35–1.04)

 

 T/T

10 (5.6)

8 (9.2)

0.48 (0.18–1.30)

 

 Total

180 (100)

87 (100)

  

Genotypes (dominant)

    

 G/G

117 (65)

45 (51.7)

1.00

0.04

 G/T-T/T

63 (35)

42 (48.3)

1.73 (1.02–2.95)

 

Genotypes (recessive)

    

 G/G-G/T

170 (94.4)

79 (90.8)

1.00

0.27

 T/T

10 (5.6)

8 (9.2)

1.72 (0.66–4.68)

 

HWEc

X2 = 1.484, P = 0.48

X2 = 0.1867, P = 0.91

  

IL-1β 315C/T

    

Allele Frequency

    

 C

269 (76)

130 (75)

1.00

0.83

 T

87 (24)

44 (25)

1.047 (0.68–1.59)

 

 Total

356 (100)

174 (100)

  

Genotype(codominant)

    

 C/C

103 (57.9)

53 (60.9)

1.00

0.25

 C/T

63 (35.4)

24 (27.6)

1.73 (0.84–3.56)

 

 T/T

12 (6.7)

10 (11.5)

0.81 (0.26–2.52)

 

 Total

178 (100)

87 (100)

  

Genotype(dominant)

    

 C/C

103 (57.9)

53 (60.9)

1.00

0.63

 C/T-T/T

75 (42.1)

34 (39.1)

0.881 (0.52–1.49)

 

Genotype (recessive)

    

 C/C–C/T

166 (93.3)

77 (88.5)

1.00

0.19

 T/T

12 (6.7)

10 (11.5)

1.797 (0.73–4.10)

 

HWEc

X2 = 0.3557, P = 0.84

X2 = 6.446, P = 0.04

  
  1. CSFP coronary slow flow phenomenon
  2. aSignificant P values if ≤ 0.05
  3. bOR: odds ratio, 95% CI 95%: confidence interval
  4. cHardy–Weinberg equilibrium