Fig. 5From: Agonist-induced Piezo1 activation promote mitochondrial-dependent apoptosis in vascular smooth muscle cellsPiezo1 promotes ROS production, calcium overload, loss of mitochondrial membrane potential, Cyt c release, up-regulation of Bax/Bcl-2 ratio, activation of caspase-3 and caspase-9, and ultimately induces mitochondrial-dependent VSMCs apoptosisBack to article page