Table 2 AEs, ADRs, thrombocytopenia and bleeding stratified by baseline criteria
Items | AEs | P value | ADRs | P value | Thrombocytopenia | P value | Bleeding | P value |
|---|---|---|---|---|---|---|---|---|
Age, no. (%) | 0.041 | 0.168 | 0.282 | 0.236 | ||||
> 75 years | 49 (22.9) | 12 (5.6) | 6 (2.8) | 6 (2.8) | ||||
≤ 75 years | 175 (17.0) | 37 (3.6) | 18 (1.7) | 15 (1.5) | ||||
Gender, No. (%) | 0.968 | 0.182 | 0.088 | 0.471 | ||||
Male | 165 (18.0) | 32 (3.5) | 14 (1.5) | 14 (1.5) | ||||
Female | 59 (17.9) | 17 (5.2) | 10 (3.0) | 7 (2.1) | ||||
BMI, No. (%) | 0.776 | 0.424 | 0.254 | 1.000 | ||||
> 28 kg/m2 | 20 (19.8) | 2 (2.0) | 0 (0.0) | 1 (1.0) | ||||
≤ 28 kg/m2 | 195 (18.6) | 44 (4.2) | 23 (2.2) | 18 (1.7) | ||||
History of diabetes mellitus, No. (%) | 0.071 | 0.135 | 0.301 | 0.407 | ||||
Yes | 55 (21.9) | 14 (5.6) | 7 (2.8) | 6 (2.4) | ||||
No | 169 (17.0) | 35 (3.5) | 17 (1.7) | 15 (1.5) | ||||
History of allergy, No. (%) | 0.847 | 0.772 | 0.682 | 0.654 | ||||
Yes | 15 (17.2) | 4 (4.6) | 2 (2.3) | 2 (2.3) | ||||
No | 209 (18.1) | 45 (3.9) | 22 (1.9) | 19 (1.6) | ||||
History of cardiac surgery, No. (%) | 0.008 | 0.009 | 0.005 | 0.282 | ||||
Yes | 19 (30.6) | 7 (11.3) | 5 (8.1) | 2 (3.2) | ||||
No | 205 (17.3) | 42 (3.6) | 19 (1.6) | 19 (1.6) | ||||
History of critical respiratory disease, No. (%) | < 0.001 | 0.650 | 1.000 | 0.463 | ||||
Yes | 16 (44.4) | 2 (5.6) | 0 (0.0) | 1 (2.8) | ||||
No | 208 (17.2) | 47 (3.9) | 24 (2.0) | 20 (1.7) | ||||
History of renal function impairment, No. (%) | 0.043 | 0.009 | 0.065 | 0.051 | ||||
Yes | 8 (36.4) | 4 (18.2) | 2 (9.1) | 2 (9.1) | ||||
No | 216 (17.7) | 45 (3.7) | 22 (1.8) | 19 (1.6) | ||||
CRUSADE risk stratification, No. (%) | 0.075 | < 0.001 | 0.009 | 0.011 | ||||
Very low risk (≤ 20) | 55 (16.8) | 11 (3.4) | 3 (0.9) | 4 (1.2) | ||||
Low risk (21–30) | 56 (16.0) | 3 (0.9) | 2 (0.6) | 1 (0.3) | ||||
Moderate risk (31–40) | 53 (19.1) | 17 (6.1) | 11 (4.0) | 6 (2.2) | ||||
High risk (41–50) | 24 (15.3) | 7 (4.5) | 3 (1.9) | 4 (2.5) | ||||
Very high risk (> 50) | 31 (27.4) | 11 (9.7) | 5 (4.4) | 6 (5.3) | ||||
Unknown | 5 (26.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
Operative timing, No. (%) | < 0.001 | 0.749 | 0.004 | 0.033 | ||||
Elective operation | 31 (10.1) | 13 (4.2) | 12 (3.9) | 1 (0.3) | ||||
Emergency operation | 193 (20.6) | 36 (3.8) | 12 (1.3) | 20 (2.1) | ||||
Types of coronary interventional therapy, No. (%) | 0.101 | 0.640 | 0.958 | 0.965 | ||||
Stent implantation | 207 (17.5) | 48 (4.1) | 23 (1.9) | 20 (1.7) | ||||
Balloon dilatation | 16 (28.6) | 1 (1.8) | 1 (1.8) | 1 (1.8) | ||||
Thrombus aspiration | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
Others | 1 (25.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
Types of stents, No. (%) | 0.564 | 0.837 | 0.643 | 0.931 | ||||
Drug stent | 202 (17.7) | 47 (4.1) | 23 (2.0) | 19 (1.7) | ||||
Bare stent | 5 (11.9) | 1 (2.4) | 0 (0.0) | 1 (2.4) | ||||
Others | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
Arterial access, No. (%) | 0.568 | 0.868 | 0.715 | 0.974 | ||||
Radial artery | 215 (18.2) | 46 (3.9) | 22 (1.9) | 20 (1.7) | ||||
Femoral artery | 9 (14.8) | 3 (4.9) | 2 (3.3) | 1 (1.6) | ||||
Brachial artery | 0 (0.0) | 0 (0.0) | 0 (0.0 | 0 (0.0) | ||||
Others | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
Culprit vessel, No. (%) | 0.224 | 0.836 | 0.777 | 0.548 | ||||
Single | 183 (17.4) | 41 (3.9) | 20 (1.9) | 17 (1.6) | ||||
Multiple | 40 (21.1) | 8 (4.2) | 4 (2.1) | 4 (2.1) | ||||
Administration of bivalirudin, No. (%) | 0.112 | 0.355 | 0.408 | 0.830 | ||||
Preoperative or intraoperative | 9 (20.5) | 3 (6.8) | 2 (4.5) | 1 (2.3) | ||||
Postoperative ≤ 4 h | 193 (17.3) | 41 (3.7) | 20 (1.8) | 18 (1.6) | ||||
Postoperative > 4 h | 22 (26.2) | 5 (6.0) | 2 (2.4) | 2 (2.4) | ||||
Combined with GP IIb/IIIa inhibitors, no. (%) | < 0.001 | 0.002 | 0.005 | 0.267 | ||||
Yes | 192 (23.9) | 42 (5.2) | 22 (2.7) | 16 (2.0) | ||||
No | 32 (7.3) | 7 (1.6) | 2 (0.5) | 5 (1.1) |