Table 3 Clinical data of FHCM probands with the MYBPC3 gene mutations
Family | Sex | Age | Obstructive | Arrhythmia | NYHA classification | Syncope | Family history of SCD | Maximum wall thickness (mm) | Mutation site | Troponin I* (ng/ml) |
|---|---|---|---|---|---|---|---|---|---|---|
Case1 | Male | 65 | Yes | No | II | Yes | Yes | 30.9 | c.3369_3370insC | 1.29 |
Case2 | Male | 23 | Yes | No | I | No | Yes | 40.5 | c.3624delC | 0.20 |
Case3 | Female | 84 | Yes | Atrial fibrillation | IIII | No | No | 33.6 | c.3624delC | 0.31 |
Ctrl1 | Male | 61 | No | No | I | No | No | 9.8 | – | < 0.01 |
Ctrl2 | Male | 23 | No | No | I | No | No | 9.5 | – | < 0.01 |
Ctrl3 | Female | 78 | No | No | I | No | No | 10.5 | – | < 0.01 |