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Table 3 Subgroup analysis of the association between Nogo-B levels and hypertension

From: Association between high serum Nogo-B and hypertension in Chinese Han

Subgroups

Number of participants

Hypertension (%)

OR (95% CI)

P value

Low plasma Nogo-B

High plasma Nogo-B

Low plasma Nogo-B

High plasma Nogo-B

Age, years

< 59

40

37

11 (27.5)

28 (75.7)

8.202 (2.950–22.805)

< 0.01

≥ 59

31

33

12 (38.7)

23 (69.7)

3.642 (1.292–10.263)

< 0.05

Sex

Male

38

32

11 (28.9)

21 (65.6)

6.562 (0.287–18.832)

0.06

Female

33

38

12 (36.4)

30 (78.9)

4.686 (1.704–12.888)

< 0.01

Cigarette smoking

No

54

52

16 (29.6)

36 (69.2)

5.344 (2.331–12.248)

< 0.01

Yes

17

18

7 (41.2)

15 (83.3)

7.143 (0.484–24.384)

0.14

Alcohol consumption

No

57

55

17 (29.8)

40 (72.7)

6.275 (2.761–14.261)

< 0.01

Yes

14

15

6 (42.8)

11 (73.3)

3.667 (0.771–17.429)

0.12

Body mass index, kg/m 2

< 24

34

33

8 (23.5)

22 (66.7)

6.500 (2.222–19.011)

< 0.01

≥ 24

37

37

15 (40.5)

29 (78.4)

5.317 (1.914–14.766)

< 0.01

Total cholesterola, mmol/l

< 5.18

51

53

16 (31.4)

38 (71.7)

5.542 (2.390–12.848)

< 0.01

≥ 5.18

20

17

7 (35.0)

13 (76.5)

6.036 (1.417–25.710)

< 0.01

Triglyceridesa, mmol/l

< 1.70

34

34

7 (20.6)

20 (58.8)

5.510 (1.879–16.159)

< 0.01

≥ 1.70

37

36

16 (43.2)

31 (86.1)

8.137 (0.585–23.619)

0.23

Low-density lipoprotein cholesterola, mmol/l

< 3.37

56

55

20 (35.7)

40 (72.7)

4.800 (2.142–10.755)

< 0.01

≥ 3.37

15

15

3 (20.0)

11 (73.3)

11.000 (1.998–60.572)

< 0.01

High-density lipoprotein cholesterola, mmol/l

< 1.04

32

26

12 (37.5)

18 (69.2)

3.750 (1.251–11.244)

< 0.01

≥ 1.04

39

44

11 (28.2)

33 (75.0)

7.636 (0.878–19.260)

0.15

  1. Low plasma Nogo-B was defined as a value lower than the median level of plasma Nogo-B concentration, plasma Nogo-B < 434.09pg/ml; high plasma Nogo-B was defined as a value higher than the median level of plasma Nogo-B concentration, plasma Nogo-B ≥ 434.09pg/ml. In the multivariable models, confounding factors, such as age, gender, current smoking, alcohol consumption, body mass index, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were included unless the variable was used as a subgroup variable
  2. CI Confidence interval; OR Odds ratio
  3. aSubgroups by blood lipids were based on the recommendations from the Working Group on dyslipidemia in China: optimal and abnormal