Prognostic value of left atrial mechanics in cardiac light-chain amyloidosis with preserved ejection fraction: a cohort study

Table 3 Association of indices of LA mechanics with endpoint in patients with cardiac light-chain amyloidosis

Variables	Unadjusted		Adjusted (Model 1)		Adjusted (Model 2)
Variables	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Total strain, %	0.944 (0.875–0.984)	0.005	0.920 (0.875–0.968)	0.001	0.923 (0.877–0.971)	0.002
Total strain rate, s⁻¹	0.451 (0.223–0.911)	0.026	0.230 (0.091–0.578)	0.002	0.231 (0.089–0.603)	0.003
Passive strain, %	0.927 (0.867–0.991)	0.026	0.892 (0.820–0.971)	0.008	–	0.108
Passive strain rate, s⁻¹	–	0.123	–	0.058	–	0.370
Active strain, %	0.928 (0.875–0.984)	0.013	0.879 (0.812–0.952)	0.001	0.883 (0.816–0.955)	0.002
Active strain rate, s⁻¹	0.575 (0.348–0.951)	0.031	0.340 (0.165–0.700)	0.003	0.422 (0.195–0.914)	0.029
LA stiffness index	1.133 (1.044–1.229)	0.003	1.154 (1.064–1.252)	0.001	1.149 (1.059–1.247)	0.001

Model 1 adjusted for Meta-Analysis Global Group in Chronic Heart Failure risk score (including age, ejection fraction, creatinine, diabetes mellitus, chronic obstructive pulmonary disease, systolic blood pressure, body mass index, heart rate, current smoker, heart failure duration, New York Heart Association class, beta blocker use and angiotensin-converting enzyme inhibitor use) and Mayo stage 2004. Model 2 adjusted for model 1 variables + statistically significant echocardiographic indices in univariate Cox regression: GLS, E/A, E/e’ (lateral), and TAPSE
CI confidential interval, HR hazard ratio, LA left atrial
All strain values are presented as absolute values

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