Fig. 4
Whole-cell patch-clamp recording of store-operated Ca2+ current in rat left ventricular myocytes. A Whole-cell patch-clamp current recorded in Con group B Whole-cell patch-clamp current recorded in MetS group [Black line: presence of Ca2+ (1.8 mM); Blue line: absence of Ca2+ (0 mM + 2 µM Thapsigargin + 10 µM verapamil + 10 µM KB-R 7943); Orange line: BTP2 added (selective SOCE blocker, 20 μM); Green line: SOCE current (ISOCE) (= Orange—Blue)] C Comparison of ISOCE current between Con (black) and MetS (orange) groups. D The calculated maximum current of ISOCE (− 110 mV) (n = 11, and 9 cells for Con and MetS, respectively *: p < 0.05 vs. Con)