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Table 2 Comparison of patients with controlled blood pressure to those with uncontrolled blood Pressure, based on univariate analysis

From: Epidemiologic features and management of hypertension in Tunisia, the results from the Hypertension National Registry (NaTuRe HTN)

 

Patients with Known hypertension > 6 months

Controlled BP (< 140/90)

Uncontrolled BP (≥ 140/90 mmHg)

p

N

23,601

12,206

11,395

 

Age (years)

    

Median ( min–max)

Mean ± SD

65(18–118)

65.07 ± 11.9

65(18–118)

64.94 ± 12.15

65(18–104)

65.2 ± 11.6

0.022*

Male (%)

Female (%)

Sex Ratio (F/M)

10,543(44.7)

13,058 (55.3)

1.23

5371(50.9)

6835 (52.34)

1.23

5172(49.1)

6223 (47.6)

1.27

0.032

Public sector (%)

18,613 (78.9)

9361(76.7)

9252 (81.2)

 < 10–3

Ramadan inclusion (%)

15,239 (64.6)

8132(66.6)

7107 (62.4)

 < 10–3

Education level

    

Unspecified (%)

Illiterate (%)

Primary school

Secondary school

University school

7182(30.4)

5236(22.2)

5111(21.7)

4041(17.1)

2031(8.6)

3688(30.2)

2588(21.2)

2548(20.9)

2217(18.2)

1165(9.5)

3494(30.7)

2648(23.2)

2563(22.5)

1824(16)

866(7.6)

 < 10–3

Secondary/University education

6072(25.7)

3382(27.7)

2690(23.6)

 < 10–3

Health insurance coverage

    

Private insurance

National insurance

Indigent

None

Unspecified

624(2.6)

17,021(72.1)

4746(20.1)

620(2.6)

590(2.5)

331(2.7)

9012(73.8)

2275(18.6)

296(2.4)

292(2.4)

293(2.6)

8009(70.3)

2471(21.7)

324(2.8)

298(2.6)

 < 10–3

History of HTN

    

 < 1 y (%)

1 to 5 y (%)

5 to 10 y (%)

10 to 15 y (%)

 > 15 y (%)

1240 (5.3)

5922 (25.1)

6293 (26.7)

4620 (19.6)

3187 (13.5)

177 (3.7)

1 138 (24.0)

1 434 (30.3)

1 486 (31.4)

503 (10.6)

690 (5.7)

3280 (26.9)

3225 (26.4)

2261 (18.5)

148 (12.1)

 < 10–3

Smoking (%)

3226(13.7)

1525(12.5)

1701(14.9)

 < 10–3

Diabetes (%)

9730(41.2)

4738(38.8)

4992(43.8)

 < 10–3

Obesity (%)

6475(28.9)

3178 (27.4)

3297 (30.5)

 < 10–3

BMI

    

Median (min–max)

Mean ± SD

27.5(13–72)

28.1 ± 4.5

27.4(13.7–67)

27.9 ± 4.5

27.6(14.6–72)

28.4 ± 4.6

 < 10–3*

Moderate Renal Failure (%)

1479(6.3)

692(5.7)

787(6.9)

 < 10–3

Hypothyroidism (%)

1289(5.5)

679(5.6)

610(5.4)

0.4

Confirmed Apnea syndrome (%)

443(1.9)

201(1.6)

242(2.1)

0.004

COPD (%)

502(2.1)

248(2)

254(2.2)

0.3

Stroke histoty (%)

1608(6.8)

765(6.3)

843(7.4)

 < 10–3

Coronary disease (%)

4579(19.4)

2433(19.9)

2146(18.8)

0.033

Median Heart rate

Mean Heart rate ± SD (bpm)

73(40–150)

73.6 ± 11

71(40–150)

72.4 ± 10.5

75(40–150)

74.8 ± 11.3

 < 10–3*

Heart rate > 80 bpm (%)

4328(18.3)

1773(14.6)

2555(22.6)

 < 10–3

LVH on EKG or TTE (%)

2728(11.6)

1213(9.9)

1515(13.3)

 < 10–3

Atrial fibrillation (%)

1834(7.8)

970(7.9)

864(7.6)

0.3

Recent lab tests < 6 months

13,799(58.5)

7331(60.1)

6468(56.8)

 < 10–3

Fasting Glucose (mg/dl)

    

Median (min–max)

Mean ± SD)

1.1(0.5–3.9)

1.3 ± 0.5

1.1(0.5–3.9)

1.6 ± 4.4

1.2(0.5–3.9)

1.9 ± 6.1

 < 10–3*

Creatinine (µmol/l)

Median ( min–max)

Mean ± SD)

82(30–700)

93.07 ± 51.3

80(30–700)

90.7 ± 47.3

83(32–681)

95.5 ± 55.2

 < 10–3*

Creatinine clearance (ml/min)

    

Median ( min–max)

Mean ± SD)

87.9(7–287)

89.9 ± 33.5

89(7.34–287)

91.2 ± 32

86.5(7.8–264)

88 ± 34

 < 10–3*

Total Cholesterol (mg/dl)

    

Median ( min–max)

Mean ± SD)

1.8(1–5)

1.9 ± 0.6

1.8(1–5)

1.8 ± 0.6

1.8(1–5)

1.93 ± 0.6

0.01*

K + (mmol/l)

    

Median (min–max)

Mean ± SD)

4.1(2.4–7)

4.1 ± 0.46

4.1(2–7)

4.1 ± 0.45

4.1(2.5–7)

4.1 ± 0.5

0.3*

Proteinuria ( +)

1306(5.5)

616(10.7)

690(13.3)

 < 10–3

Drug treatment

    

No drug (%)

Monotherapy (%)

Bitherapy (%)

Tritherapy or more (%)

3202(13.6)

10,959(46.4)

6318(26.8)

3122(13.2)

1583(13)

6294(51.6)

3131(25.7)

1198(9.8)

1619(14.2)

4665(40.9)

3187(28.0)

1924(16.9)

 < 10–3

Hypertensive drug

ACE (%)

10,734(45.5)

5602(45.9)

5132(45)

0.18

ARB (%)

5265(22.3)

3033(24.8)

2232(19.6)

 < 10–3

CCB (%)

7324(31)

3739(30.6)

3585(31.5)

0.16

Diuretics (%)

5018(21.3)

2643(21.7)

2375(20.8)

0.12

Betablockers (%)

5239(22.2)

2726(22.3)

2513(22.1)

0.6

One single pill therapy (%)

1506 (6.3)

766 (3.2)

740 (3.4)

0.829

Salt restriction (%)

13,294(56.3)

8189(67.1)

5105(44.8)

 < 10–3

ABPM (%)

493(2.1)

231(1.9)

262(2.3)

0.02

SMBP (%)

1464(6.2)

758(6.2)

706(6.2)

0.9

Drug compliance (%)

18,824(79.8)

10,566(86.6)

8258(72.5)

 < 10–3

Physical activity (%)

3524(14.9)

2210(18.1)

1314(11.5)

 < 10–3

  1. *Mann–Whitney nonparametric test
  2. ABPM: Ambulatory blood pressure monitoring, ACE: Antagonist of conversion enzyme, ARB: Angiotensin Receptor Blockers, BMI: Body mass Index, CCB: Calcium Channels Blockers, COPD: Chronic obstructive pulmonary disease, DBP: Diastolic Blood Pressure, EKG: electrocardiogram, HTN: hypertension, LVH: Left Ventricle Hypertrophy, SD: Standard Deviation, SBP: systolic Blood Pressure, SMBP: Self measured Blood Pressure, TTE: Transthoracic echocardiography, Yo: year-old,