Table 5 Association of ALDH2 rs671 and MTHFR rs1801133 polymorphisms with hypertension
SNP | Model | Genotype | Hypertension | Control | Univariate OR (95% CI) | P values | Multivariate OR (95% CI) | P values* |
|---|---|---|---|---|---|---|---|---|
ALDH2 rs671 | Co-dominant | G/G | 1442 (47.17%) | 1029 (46.46%) | 1.000 (reference) | Â | Â | Â |
|  |  | G/A | 1358 (44.42%) | 970 (43.79%) | 1.178 (0.966–1.435) | 0.105 | 1.251 (1.024–1.528) | 0.028 |
|  |  | A/A | 257 (8.41%) | 216 (9.75%) | 1.177 (0.965–1.435) | 0.109 | 1.191 (0.975–1.455) | 0.087 |
| Â | Dominant | G/G | 1442 (47.17%) | 1029 (46.46%) | 1.000 (reference) | Â | Â | Â |
|  |  | G/A + A/A | 1615 (52.83%) | 1186 (53.54%) | 1.029 (0.922–1.148) | 0.608 | 1.082 (0.968–1.209) | 0.166 |
|  | Recessive | G/G + G/A | 2800 (91.59%) | 1999 (90.25%) | 1.000 (reference) |  |  |  |
|  |  | A/A | 257 (8.41%) | 216 (9.75%) | 1.177 (0.974–1.423) | 0.092 | 1.221 (1.008–1.478) | 0.041 |
MTHFR rs1801133 | Co-dominant | C/C | 1555 (50.87%) | 1264 (57.07%) | 1.000 (reference) | Â | Â | Â |
|  |  | C/T | 1287 (42.10%) | 816 (36.84%) | 1.295 (1.031–1.626) | 0.026 | 1.307 (1.039–1.643) | 0.022 |
|  |  | T/T | 215 (7.03%) | 135 (6.09%) | 1.010 (0.800–1.274) | 0.935 | 1.024 (0.810–1.294) | 0.844 |
| Â | Dominant | C/C | 1555 (50.87%) | 1264 (57.07%) | 1.000 (reference) | Â | Â | Â |
|  |  | C/T + T/T | 1502 (49.13%) | 951 (42.93%) | 1.284 (1.150–1.433) | < 0.001 | 1.281 (1.146–1.430) | < 0.001 |
|  | Recessive | C/C + C/T | 2842 (92.97%) | 2080 (93.91%) | 1.000 (reference) |  |  |  |
|  |  | T/T | 215 (7.03%) | 135 (6.09%) | 1.166 (0.933–1.456) | 0.177 | 1.179 (0.942–1.475) | 0.150 |