Table 4 Clinical characteristics of hypertensive patients stratified by MTHFR rs1801133 genotypes and alleles
Clinical characteristics | C/C (n = 1555) | C/T (n = 1287) | T/T (n = 215) | P values | C allele (C/C + C/T) (n = 2842) | T allele (C/T + T/T) (n = 1502) | P values |
|---|---|---|---|---|---|---|---|
Age, years | 67.26 ± 11.87 | 67.63 ± 11.63 | 65.90 ± 11.96 | 0.130 | 67.43 ± 11.76 | 67.38 ± 11.69 | 0.908 |
Gender | Â | Â | Â | Â | Â | Â | Â |
 Male, n (%) | 1087 (69.90%) | 812 (63.09%) | 141 (65.58%) | 0.001 | 1899 (66.82%) | 953 (63.45%) | 0.027 |
 Female, n (%) | 468 (30.10%) | 475 (36.91%) | 74 (34.42%) |  | 943 (33.18%) | 549 (36.55%) |  |
Smokers, n (%) | 438 (28.17%) | 308 (23.93%) | 53 (24.65%) | 0.033 | 746 (26.25%) | 361 (24.03%) | 0.111 |
Alcoholism, n (%) | 76 (4.89%) | 69 (5.36%) | 12 (5.58%) | 0.811 | 145 (5.10%) | 81 (5.39%) | 0.681 |
Diabetes, n (%) | 497 (31.96%) | 396 (30.77%) | 57 (26.51%) | 0.257 | 893 (31.42%) | 453 (30.16%) | 0.392 |
SBP, mmHg | 152.90 ± 25.40 | 152.38 ± 46.09 | 149.16 ± 24.17 | 0.351 | 152.66 ± 36.26 | 151.92 ± 43.64 | 0.548 |
DBP, mmHg | 87.10 ± 15.49 | 86.92 ± 15.50 | 86.59 ± 15.08 | 0.881 | 87.02 ± 15.49 | 86.87 ± 15.44 | 0.765 |
Hcy, μmol/L | 16.31 ± 6.34 | 17.22 ± 7.63 | 23.32 ± 16.03 | < 0.001 | 16.72 ± 6.96 | 18.09 ± 9.54 | < 0.001 |
TG, mmol/L | 1.81 ± 1.65 | 1.82 ± 1.44 | 1.81 ± 1.69 | 0.999 | 1.81 ± 1.56 | 1.82 ± 1.48 | 0.982 |
TC, mmol/L | 4.95 ± 1.31 | 4.90 ± 1.32 | 4.95 ± 1.25 | 0.574 | 4.93 ± 1.32 | 4.91 ± 1.31 | 0.620 |
HDL-C, mmol/L | 1.27 ± 0.39 | 1.26 ± 0.37 | 1.27 ± 0.34 | 0.858 | 1.27 ± 0.38 | 1.26 ± 0.37 | 0.738 |
LDL-C, mmol/L | 2.78 ± 0.91 | 2.74 ± 0.94 | 2.79 ± 0.93 | 0.568 | 2.76 ± 0.93 | 2.75 ± 0.94 | 0.691 |
Apo-A1, g/L | 1.12 ± 0.31 | 1.12 ± 0.32 | 1.13 ± 0.29 | 0.888 | 1.12 ± 0.32 | 1.12 ± 0.31 | 0.898 |
Apo-B, g/L | 0.86 ± 0.27 | 0.86 ± 0.28 | 0.88 ± 0.27 | 0.644 | 0.86 ± 0.28 | 0.86 ± 0.28 | 0.888 |