Table 3 Clinical characteristics of hypertensive patients stratified by ALDH2 rs671 genotypes and alleles
Clinical characteristics | G/G (n = 1442) | G/A (n = 1358) | A/A (n = 257) | P values | G allele (G/G + G/A) (n = 2800) | A allele (G/A + A/A) (n = 1615) | P values |
|---|---|---|---|---|---|---|---|
Age, years | 66.62 ± 11.98 | 67.79 ± 11.55 | 68.79 ± 11.66 | 0.004 | 67.18 ± 11.78 | 67.95 ± 11.57 | 0.037 |
Gender | Â | Â | Â | Â | Â | Â | Â |
 Male, n (%) | 1041 (72.19%) | 834 (61.41%) | 165 (64.20%) | < 0.001 | 1875 (66.96%) | 999 (61.86%) | 0.001 |
 Female, n (%) | 401 (27.81%) | 524 (38.59%) | 92 (35.80%) |  | 925 (33.04%) | 616 (38.14%) |  |
Smokers, n (%) | 422 (29.26%) | 322 (23.71%) | 55 (21.40%) | 0.001 | 744 (26.57%) | 377 (23.34%) | 0.018 |
Alcoholism, n (%) | 104 (7.21%) | 49 (3.61%) | 4 (1.56%) | < 0.001 | 153 (5.46%) | 53 (3.28%) | 0.001 |
Diabetes, n (%) | 432 (29.96%) | 442 (32.55%) | 76 (29.57%) | 0.289 | 874 (31.21%) | 518 (32.07%) | 0.568 |
SBP, mmHg | 154.94 ± 24.30 | 149.42 ± 25.26 | 154.07 ± 91.08 | < 0.001 | 152.27 ± 24.92 | 150.16 ± 43.07 | 0.040 |
DBP, mmHg | 88.84 ± 15.36 | 85.52 ± 15.20 | 84.38 ± 16.25 | < 0.001 | 87.23 ± 15.37 | 85.34 ± 15.37 | < 0.001 |
Hcy, μmol/L | 17.52 ± 8.83 | 16.81 ± 7.19 | 17.29 ± 8.57 | 0.066 | 17.18 ± 8.08 | 16.89 ± 7.42 | 0.236 |
TG, mmol/L | 1.82 ± 1.67 | 1.80 ± 1.43 | 1.85 ± 1.65 | 0.889 | 1.81 ± 1.56 | 1.81 ± 1.47 | 0.997 |
TC, mmol/L | 4.97 ± 1.32 | 4.87 ± 1.30 | 5.03 ± 1.32 | 0.062 | 4.92 ± 1.31 | 4.90 ± 1.30 | 0.531 |
HDL-C, mmol/L | 1.28 ± 0.39 | 1.26 ± 0.38 | 1.25 ± 0.35 | 0.243 | 1.27 ± 0.38 | 1.26 ± 0.37 | 0.296 |
LDL-C, mmol/L | 2.80 ± 0.92 | 2.70 ± 0.92 | 2.87 ± 0.98 | 0.003 | 2.75 ± 0.92 | 2.73 ± 0.93 | 0.457 |
Apo-A1, g/L | 1.12 ± 0.31 | 1.11 ± 0.31 | 1.10 ± 0.32 | 0.545 | 1.12 ± 0.31 | 1.11 ± 0.31 | 0.496 |
Apo-B, g/L | 0.87 ± 0.28 | 0.84 ± 0.27 | 0.89 ± 0.30 | 0.006 | 0.86 ± 0.27 | 0.85 ± 0.28 | 0.376 |