Table 4 Temporal trends in in-hospital and 1-year-outcomes in patients with advanced CKD (G3b-G5)
| Â | Time period | |||
|---|---|---|---|---|
T1 2006–2010 (n = 407) | T2 2011–2015 (n = 313) | T3 2016–2019 (n = 298) | Significance | |
In hospital events | ||||
 Resuscitations (%) | 6.9 | 8.9 | 13.1 | < 0.01 |
 Cerebrovascular events/TIA (%) | 0.5 | 0.9 | 1.0 | 0.58 |
 TIMI minimal bleedings (%) | 10.7 | 10.8 | 21.1 | < 0.01 |
 TIMI minor bleedings (%) | 3.2 | 1.6 | 2.7 | 0.49 |
 TIMI major bleedings (%) | 2.2 | 1.9 | 6.7 | < 0.01 |
 Overall mortality (%) | 26.6 | 29.3 | 30.6 | 0.18 |
 Acute kidney injury (KDIGO stage 1 + (%)) | 38.3 | 44.8 | 41.6 | 0.47 |
Adverse events at 1Â year | ||||
 In-stent-thrombosis (ST) (%) | 3.0 | 1.3 | 1.0 | 0.047 |
 Myocardial re-infarction (AMI) (%) | 7.1 | 5.4 | 3.1 | < 0.01 |
 Repeat target lesion revascularisation (TLR) (%) | 3.3 | 0.3 | 1.5 | 0.04 |
Cumulative isch. events (ST + AMI + TLR) (%) | 10.8 | 5.7 | 3.1 | < 0.01 |
Cerebrovascular events/TIA (%) | 3.0 | 3.3 | 2.7 | 0.74 |
Overall mortality (%) | 46.9 | 47.7 | 51.5 | 0.29 |
Bleeding events after hospital discharge (%) | 2.0 | 6.0 | 5.5 | 0.044 |
Cumulative bleeding events (TIMI minor + major + any bleeding event after discharge.) (%) | 6.9 | 8.9 | 13.4 | < 0.01 |
Adverse events at 5Â years | ||||
 Overall mortality (%) | 67.2 | 66.4 | – | 0.72 |