| Men (n = 1343) |  |  |  |  |  |  |  |  | Women (n = 2398) |  |  |  |  |  |  |  |  |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | 0–1 type |  | 2 types |  |  | 3 or more types |  |  |  | 0–1 type |  | 2 types |  |  | 3 or more types |  |  |  |
 | n = 771 |  | n = 314 |  |  | n = 258 |  |  | Trend test | n = 927 |  | n = 847 |  |  | n = 624 |  |  | Trend test |
 |  |  | HR | 95% CI | P value | HR | 95% CI | P value | P value |  |  | HR | 95% CI | P value | HR | 95% CI | P value | P value |
CVD | 36 | Â | Â | 7 | Â | 11 | Â | Â | Â | 18 | Â | 12 | Â | Â | 8 | Â | Â | Â |
Sex and age adjusted model | 1.00 | (Ref) | 0.50 | (0.22–1.12) | 0.090 | 0.84 | (0.43–1.66) | 0.619 | 0.361 | 1.00 | (Ref) | 0.70 | (0.34–1.45) | 0.334 | 0.50 | (0.22–1.15) | 0.101 | 0.091 |
Multivariable adjusted model | 1.00 | (Ref) | 0.48 | (0.20–1.17) | 0.106 | 0.62 | (0.26–1.48) | 0.281 | 0.152 | 1.00 | (Ref) | 0.66 | (0.30–1.45) | 0.300 | 0.39 | (0.19–0.98) | 0.046 | 0.042 |
Stroke | 28 | Â | 4 | Â | Â | 9 | Â | Â | Â | 17 | Â | 10 | Â | Â | 5 | Â | Â | Â |
Sex and age adjusted model | 1.00 | (Ref) | 0.36 | (0.13–1.04) | 0.059 | 0.89 | (0.42–1.90) | 0.765 | 0.430 | 1.00 | (Ref) | 0.62 | (0.28–1.35) | 0.228 | 0.33 | (0.12–0.89) | 0.028 | 0.022 |
Multivariable adjusted model | 1.00 | (Ref) | 0.40 | (0.13–1.17) | 0.094 | 0.68 | (0.26–1.79) | 0.431 | 0.243 | 1.00 | (Ref) | 0.54 | (0.24–1.25) | 0.149 | 0.23 | (0.07–0.70) | 0.010 | 0.006 |
 | Total (n = 3741) |  |  |  |  |  |  |  |  |
---|---|---|---|---|---|---|---|---|---|
 | 0–1 type |  | 2 types |  |  | 3 or more types |  |  |  |
 | n = 1,698 |  | n = 1,161 |  |  | n = 882 |  |  | Trend test |
 |  |  | HR | 95% CI | P value | HR | 95% CI | P value | P value |
CVD | 54 | Â | 19 | Â | Â | 19 | Â | Â | Â |
Sex and age adjusted model | 1.00 | (Ref) | 0.61 | (0.36–1.04) | 0.068 | 0.66 | (0.39–1.12) | 0.121 | 0.071 |
Multivariable adjusted model | 1.00 | (Ref) | 0.51 | (0.28–0.94) | 0.031 | 0.49 | (0.26–0.93) | 0.030 | 0.013 |
Stroke | 45 | Â | 14 | Â | Â | 14 | Â | Â | Â |
Sex and age adjusted model | 1.00 | (Ref) | 0.52 | (0.29–0.96) | 0.037 | 0.57 | (0.31–1.04) | 0.066 | 0.032 |
Multivariable adjusted model | 1.00 | (Ref) | 0.48 | (0.24–0.96) | 0.039 | 0.43 | (0.20–0.92) | 0.030 | 0..014 |