Table 1 Main characteristics of the included studies
Study | Year | Country | Ethnicity | Sample size | Quality | HWE | ApoE ε2 (n) | ApoE ε3 (n) | ApoE ε4 (n) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | Score | Y/N | Case | Control | Case | Control | Case | Control | ||||
Cumming et al | 1984 | Scotland | Scottish | 239 | 239 | 7 | Y (P = 0.57) | 28 | 39 | 351 | 367 | 99 | 70 |
Yamamura et al | 1984 | Germany | Caucasian | 523 | 1031 | 6 | N (P < 0.01) | 93 | 379 | 826 | 1594 | 127 | 09 |
Utermann et al | 1984 | Japan | Japanese | 523 | 1031 | 5 | N (P = 0.01) | 93 | 379 | 826 | 1594 | 127 | 309 |
Lenzen et al | 1986 | Germany | Caucasian | 570 | 624 | 8 | Y (P = 0.16) | 63 | 99 | 907 | 978 | 170 | 171 |
Luc et al | 1994 | Belfast | Caucasian | 183 | 176 | 7 | Y (P = 0.57) | 25 | 36 | 270 | 266 | 71 | 50 |
Luc et al | 1994 | Lille | Caucasian | 64 | 150 | 7 | Y (P = 0.98) | 6 | 33 | 105 | 223 | 17 | 44 |
Luc et al | 1994 | Strasbourg | Caucasian | 187 | 172 | 7 | Y (P = 0.51) | 27 | 29 | 288 | 274 | 59 | 41 |
Luc et al | 1994 | Toulouse | Caucasian | 140 | 182 | 7 | Y (P = 0.84) | 16 | 20 | 228 | 311 | 36 | 33 |
Joven et al | 1998 | Spain | Caucasian | 250 | 250 | 6 | Y (P = 0.19) | 39 | 25 | 397 | 438 | 64 | 37 |
Nakai et al | 1998 | Japan | Japanese | 254 | 422 | 6 | Y (P = 0.29) | 12 | 20 | 418 | 744 | 66 | 80 |
Batalla et al | 2000 | Spain | Spainish | 220 | 200 | 8 | Y (P = 0.89) | 10 | 19 | 389 | 348 | 41 | 33 |
Zhao et al | 2000 | Liaoning | Asian | 50 | 49 | 7 | Y (P = 0.76) | 4 | 5 | 90 | 90 | 6 | 3 |
Raslová et al | 2001 | Slovak | Caucasian | 71 | 71 | 6 | Y (P = 0.30) | 12 | 7 | 111 | 114 | 13 | 17 |
Wang et al | 2001 | Xinjiang | Asian | 54 | 106 | 6 | Y (P = 0.58) | 3 | 15 | 82 | 174 | 23 | 23 |
Gong et al | 2001 | Guangdong | Asian | 108 | 115 | 7 | Y (P = 0.47) | 14 | 16 | 170 | 196 | 32 | 18 |
Bai et al | 2001 | Liaoning | Asian | 47 | 113 | 6 | Y (P = 0.36) | 4 | 11 | 90 | 200 | 6 | 9 |
Kolovou et al | 2002 | Greece, | Greek | 267 | 240 | 7 | Y (P = 0.72) | 39 | 39 | 412 | 392 | 83 | 49 |
Mamotte et al | 2002 | Australia | Caucasian | 359 | 639 | 6 | Y (P = 1.54) | 39 | 92 | 554 | 983 | 125 | 203 |
Kumar et al | 2003 | North India | Indian | 35 | 45 | 5 | N (P = 0.03) | 7 | 13 | 36 | 73 | 27 | 4 |
Li et al | 2003 | Nantong | Asian | 67 | 152 | 5 | Y (P = 0.10) | 16 | 26 | 98 | 253 | 22 | 25 |
Chen et al | 2003 | Liaoning | Asian | 50 | 110 | 5 | Y (P = 0.09) | 4 | 11 | 90 | 92 | 6 | 3 |
Keavney et al | 2004 | UK | Caucasian | 4484 | 5757 | 6 | N (P < 0.01) | 440 | 686 | 6778 | 8830 | 1206 | 1376 |
Ranjith et al | 2004 | Indian | African | 195 | 300 | 6 | N (P < 0.01) | 10 | 27 | 330 | 517 | 50 | 56 |
Aasvee et al | 2006 | estonia | Caucasian | 71 | 85 | 8 | Y (P = 0.98) | 7 | 18 | 110 | 133 | 23 | 21 |
Baum et al | 2006 | Hongkong | chinese | 231 | 311 | 6 | Y (P = 0.81) | 17 | 70 | 387 | 505 | 58 | 47 |
Koch et al | 2008 | Germany | Caucasian | 3657 | 1211 | 6 | Y (P = 0.72) | 517 | 201 | 5769 | 1899 | 1028 | 322 |
Viitanen et al | 2011 | Finland | Caucasian | 118 | 110 | 5 | Y (P = 0.98) | 7 | 10 | 171 | 175 | 58 | 35 |
Onrat et al | 2012 | Turkey | Turkish | 100 | 36 | 6 | Y (P = 0.55) | 12 | 4 | 172 | 62 | 16 | 6 |
Tanguturi et al | 2013 | India | Indian | 202 | 210 | 8 | Y (P = 0.18) | 12 | 17 | 329 | 371 | 63 | 32 |
Kukava et al | 2017 | Russia | Russians | 405 | 198 | 7 | Y (P = 0.50) | 68 | 32 | 698 | 326 | 44 | 38 |
Gupta et al | 2018 | India | Indian | 168 | 89 | 6 | Y (P = 0.54) | 18 | 4 | 302 | 165 | 16 | 9 |
Hu et al | 2020 | Jiangxi | Asian | 53 | 632 | 7 | N (P = 0.02) | 128 | 28 | 1055 | 83 | 81 | 23 |