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Table 5 The association between three NPAR groups and 180-day all-cause mortality in subgroup analysis

From: The neutrophil percentage-to-albumin ratio is associated with all-cause mortality in critically ill patients with acute myocardial infarction

 

N

NPAR < 21.58

(reference)

21.58 ≤ NPAR < 26.77

HR (95% CIs)

NPAR ≥ 26.77

HR (95% CIs)

p for interaction

AF

0.4736

No

551

1.0

1.42 (0.90, 2.23)

2.80 (1.85, 4.26)

 

Yes

247

1.0

1.55 (0.86, 2.81)

2.19 (1.26, 3.82)

 

CHF

0.1939

No

422

1.0

1.18 (0.68, 2.07)

2.89 (1.79, 4.67)

 

Yes

376

1.0

1.60 (0.99, 2.59)

2.30 (1.45, 3.65)

 

CKD

0.5369

No

690

1.0

1.54 (1.04, 2.27)

2.53 (1.76, 3.64)

 

Yes

108

1.0

1.21 (0.47, 3.13)

3.12 (1.35, 7.22)

 

COPD

0.9520

No

784

1.0

1.50 (1.04, 2.16)

2.62 (1.87, 3.67)

 

Yes

14

1.0

2.42 (0.15, 39.05)

3.37 (0.40, 28.33)

 

CAD

0.8694

No

253

1.0

1.72 (0.92, 3.23)

2.54 (1.48, 4.36)

 

Yes

545

1.0

1.45 (0.94, 2.26)

2.49 (1.61, 3.83)

 

Hypertension

0.3855

No

453

1.0

1.19 (0.74, 1.91)

2.34 (1.54, 3.55)

 

Yes

345

1.0

1.95 (1.11, 3.41)

2.86 (1.64, 4.98)

 

Diabetes

0.3603

No

567

1.0

1.36 (0.90, 2.06)

2.32 (1.58, 3.40)

 

Yes

231

1.0

1.99 (0.96, 4.13)

3.91 (1.99, 7.70)

 

Prior MI

0.4050

No

752

1.0

1.54 (1.06, 2.25)

2.84 (2.01, 4.02)

 

Yes

46

1.0

1.09 (0.33, 3.57)

1.20 (0.35, 4.13)

 

Stroke

0.4004

No

768

1.0

1.52 (1.05, 2.20)

2.75 (1.95, 3.88)

 

Yes

30

1.0

0.69 (0.16, 2.91)

0.92 (0.24, 3.58)

 

Clopidogre

0.4357

No

401

1.0

1.22 (0.75, 1.99)

2.37 (1.55, 3.61)

 

Yes

397

1.0

1.97 (1.14, 3.41)

3.04 (1.77, 5.20)

 

Aspirin

0.4040

No

191

1.0

0.98 (0.47, 2.05)

1.93 (1.08, 3.46)

 

Yes

607

1.0

1.73 (1.14, 2.62)

2.85 (1.90, 4.28)

 

Metoprolol

0.8271

No

236

1.0

1.30 (0.72, 2.35)

1.98 (1.17, 3.35)

 

Yes

562

1.0

1.53 (0.97, 2.41)

2.59 (1.68, 4.00)

 

ACEI/ARBs

0.3793

No

371

1.0

1.33 (0.83, 2.14)

2.21 (1.48, 3.31)

 

Yes

427

1.0

1.98 (1.13, 3.47)

2.19 (1.19, 4.03)

 

Statin

0.2013

No

242

1.0

1.25 (0.73, 2.15)

1.68 (1.04, 2.72)

 

Yes

556

1.0

1.67 (1.03, 2.71)

3.08 (1.94, 4.86)

 

PTCA/PCI

0.2614

No

313

1.0

1.19 (0.71, 1.99)

1.73 (1.10, 2.74)

 

Yes

485

1.0

1.69 (1.02, 2.80)

3.08 (1.89, 5.02)

 

Gender

0.7209

Female

294

1.0

1.37 (0.76, 2.47)

2.82 (1.65, 4.83)

 

Male

504

1.0

1.57 (1.00, 2.47)

2.52 (1.65, 3.86)

 

Race

0.5510

White

518

1.0

1.43 (0.88, 2.34)

2.84 (1.85, 4.38)

 

Black

46

1.0

2.63 (0.66, 10.56)

6.29 (1.49, 26.52)

 

Other

234

1.0

1.26 (0.70, 2.25)

1.99 (1.14, 3.48)

 

ALT (U/L)

0.6194

< 35.81

393

1.0

1.35 (0.80, 2.28)

2.88 (1.80, 4.64)

 

≥ 35.81

405

1.0

1.57 (0.95, 2.58)

2.41 (1.51, 3.86)

 

AST (U/L)

0.8455

< 67.00

391

1.0

1.44 (0.82, 2.52)

2.84 (1.71, 4.73)

 

≥ 67.00

407

1.0

1.45 (0.91, 2.32) 0

2.40 (1.55, 3.72)

 

CK-peak (U/L)

0.9398

< 823.00

397

1.0

1.46 (0.88, 2.41)

2.56 (1.64, 4.01)

 

≥ 823.00

401

1.0

1.56 (0.93, 2.63)

2.81 (1.71, 4.62)

 

CK-MB-peak (U/L)

0.9731

< 48.00

398

1.0

1.54 (0.91, 2.60)

2.69 (1.68, 4.30)

 

≥ 48.00

399

1.0

1.45 (0.89, 2.38)

2.66 (1.66, 4.28)

 

Glucose (mg/dL)

0.7956

< 148.00

395

1.0

1.53 (0.89, 2.61)

3.02 (1.85, 4.93)

 

≥ 148.00

403

1.0

1.45 (0.89, 2.36)

2.35 (1.50, 3.70)

 

PT (s)

0.2151

< 13.70

388

1.0

1.96 (1.18, 3.27)

2.82 (1.67, 4.78)

 

≥ 13.70

410

1.0

1.03 (0.62, 1.71)

2.00 (1.28, 3.13)

 

Hemoglobin (g/dL)

0.7119

< 12.40

394

1.0

1.20 (0.71, 2.03)

2.14 (1.34, 3.41)

 

≥ 12.40

404

1.0

1.62 (0.98, 2.66)

2.47 (1.47, 4.15)

 

RDW (%)

0.4510

< 13.80

394

1.0

1.37 (0.77, 2.42)

2.84 (1.65, 4.88)

 

≥ 13.80

404

1.0

1.55 (0.97, 2.47)

2.22 (1.45, 3.39)

 

Creatinine (mEq/L)

0.6118

< 1.10

303

1.0

1.76 (0.91, 3.42)

3.61 (1.91, 6.84)

 

≥ 1.10

399

1.0

1.69 (1.05, 2.73)

2.58 (1.66, 4.02)

 

BUN (mg/dL)

0.1007

< 22.00

370

1.0

2.26 (1.21, 4.21)

3.86 (2.07, 7.20)

 

≥ 22.00

414

1.0

1.11 (0.70, 1.75)

1.84 (1.23, 2.77)

 

WBC (109/L)

0.3940

< 12.00

383

1.0

1.38 (0.77, 2.46)

3.13 (1.85, 5.29)

 

≥ 12.00

401

1.0

1.40 (0.85, 2.31)

2.10 (1.32, 3.35)

 

Potassium (mmol/L)

0.5270

< 4.20

388

1.0

1.22 (0.71, 2.08)

2.43 (1.48, 3.98)

 

≥ 4.20

410

1.0

1.83 (1.13, 2.97)

2.90 (1.85, 4.54)

 

Sodium (mmol/L)

0.8463

< 139.00

384

1.0

1.64 (0.97, 2.78)

2.91 (1.77, 4.78)

 

≥ 139.00

414

1.0

1.35 (0.82, 2.24)

2.46 (1.57, 3.85)

 

Platelet (109/L)

0.9992

< 241.00

399

1.0

1.50 (0.90, 2.49)

2.68 (1.70, 4.21)

 

≥ 241.00

399

1.0

1.51 (0.91, 2.52)

2.62 (1.61, 4.29)

 

Age (years)

0.0469

< 70.00

394

1.0

1.26 (0.68, 2.32)

3.42 (1.99, 5.88)

 

≥ 70.00

404

1.0

1.58 (1.01, 2.47)

2.05 (1.35, 3.12)

 

Heart rate (beats/minute)

0.0023

< 101.00

385

1.0

2.61 (1.43, 4.77)

5.12 (2.89, 9.07)

 

≥ 101.00

413

1.0

0.92 (0.59, 1.45)

1.51 (1.00, 2.28)

 

Respiratory rate (beats/minute)

0.8764

< 26.00

368

1.0

1.44 (0.80, 2.58)

2.83 (1.65, 4.83)

 

≥ 26.00

430

1.0

1.54 (0.98, 2.44)

2.56 (1.67, 3.90)

 

MBP (mmHg)

0.4178

< 57.00

371

1.0

1.16 (0.70, 1.92)

2.23 (1.43, 3.46)

 

≥ 57.00

427

1.0

1.87 (1.12, 3.13)

2.79 (1.68, 4.66)

 

Weight (kg)

0.6674

< 78.00

392

1.0

1.76 (1.04, 2.97)

3.01 (1.84, 4.91)

 

≥ 78.00

406

1.0

1.26 (0.76, 2.08)

2.32 (1.46, 3.69)

 

ICU LOS (day)

0.0002

< 3.69

399

1.0

1.28 (0.73, 2.25)

4.33 (2.66, 7.03)

 

≥ 3.69

399

1.0

1.40 (0.87, 2.27)

1.59 (1.01, 2.52)

 

SAPS II

0.0010

< 31.00

247

1.0

8.90 (2.01, 39.44)

19.22 (4.30, 85.91)

 

≥ 31.00, < 45

278

1.0

1.10 (0.58, 2.08)

1.33 (0.72, 2.45)

 

≥ 45

273

1.0

0.96 (0.60, 1.54)

1.44 (0.95, 2.18)

 

SOFA

0.0605

< 3.00

247

1.0

2.17 (0.92, 5.11)

5.29 (2.19, 12.78)

 

≥ 3.00, < 6.00

236

1.0

1.91 (0.96, 3.82)

1.75 (0.88, 3.50)

 

≥ 6.00

315

1.0

0.95 (0.58, 1.54)

1.53 (1.00, 2.33)

 

Urine output (ml/24 h)

0.2991

< 1805.00

399

1.0

1.26 (0.79, 2.01)

1.84 (1.21, 2.82)

 

≥ 1805.00

399

1.0

1.54 (0.87, 2.73)

3.20 (1.86, 5.50)

 
  1. HR hazard ratio, CI confidence interval, AF atrial fibrillation, CHF chronic heart failure, CDK chronic kidney disease, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, prior MI prior myocardial infarction, ACEI/ARBs angiotensin-converting enzyme inhibitor/angiotensin receptor blockers, PTCA/PCI percutaneous transluminal coronary angioplasty/percutaneous coronary intervention, ALT alanine aminotransferase, AST aspartate aminotransferase, CK creatine kinase, CK-MB MB isoenzyme of creatine kinase, PT prothrombin time, RDW red cell distribution width, BUN blood urea nitrogen, WBC white blood cell, MBP mean blood pressure, ICU LOS length of ICU stay, SAPS II simplified acute physiology score II, SOFA sequential organ failure assessment score