The use of serotonin reuptake inhibitors increases the risk of bleeding in patients with assist devices

Table 3 Overview of fixed effects on bleeding rate

Groups	Estimate	Standard Error	Z value	p
Effect of SRI¹	6.695	3.201	2.091	0.037
Effect of Mirtazapine¹	9.96	9.391	1.06	0.289
Covariates
Arterial hypertension	6.33	2.762	2.292	0.022
Chronic renal failure	− 3.849	2.214	− 1.739	0.082
Nicotine abuse	− 0.652	2.176	− 0.299	0.765
Diabetes mellitus type II	− 3.160	2.994	− 1.055	0.291
Hypercholesterolemia	2.184	2.175	1.004	0.315
VAD Model	0.604	1.204	0.501	0.616

¹ compared to without antidepressant medication. SRI = serotonin reuptake inhibitors. VAD = ventricular assist device

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