Fig. 3

Endothelial function, vascular stiffness, and atherosclerotic plaque. Carotid intima media thickness (CIMT, a surrogate for atherosclerotic plaque burden), pulse wave velocity (PWV, a measure of vascular stiffness), and reactive hyperemia index (RHI, a measure of endothelial function) were similar in ApoB^R3500Q heterozygotes (gray squares) and controls (white circles) and did not correlate with LDL-C or age in either group. CIMT and RHI correlated with age in overall subjects. ApoB^R3500Q homozygotes (black triangles) were not included in statistical analysis due to small sample size but are presented for completeness. Imaging values association with LDL-C or age measured by Spearman’s rho (r_s)