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Table 4 Associations between elevated D-dimer levels and cause-specific cardiovascular disease events during 4.12 years of follow-up

From: D-dimer as a predictor of cardiovascular outcomes in patients with diabetes mellitus

D-dimer level (ng/mL)

Events/n

OR (95%CI)

P value

All-cause mortality (n = 69)

≤ 110

8/513

1

0.001

110–170

13/502

1.36 (1.19–1.67)

 

170–270

17/485

1.30 (1.13–1.66)

 

≥ 270

31/476

1.42 (1.29–1.84)

 

Acute myocardial infarction (n = 46)

≤ 110

9/513

1

0.001

110–170

10/502

1.24 (1.07–2.04)

 

170–270

10/485

1.65 (1.27–2.17)

 

≥ 270

17/476

1.98 (1.07–2.66)

 

Unstable angina (n = 50)

≤ 110

6/513

1

0.001

110–170

12/502

1.12 (1.04–1.98)

 

170–270

13/485

1.27 (1.09–2.03)

 

≥ 270

19/476

1.36 (1.04–2.18)

 

Stroke (n = 49)

≤ 110

7/513

1

0.001

110–170

9/502

1.30 (1.13–1.89)

 

170–270

11/485

1.62 (1.04–2.02)

 

≥ 270

22/476

1.78 (1.15–2.09)

 

Cardiovascular mortality (n = 47)

≤ 110

4/513

1

0.001

110–170

8/502

1.15 (1.02–1.99)

 

170–270

12/485

1.37 (1.09–2.17)

 

≥ 270

23/476

1.42 (1.10–2.38)

 
  1. OR (95% CI) and P value adjusted for treatment and traditional risk factors that remained significant after univariable logistic regression analysis: age, hypertension, BMI, smoke, LDL-cholesterol, triglyceride, HbA1C, duration of diabetes, use of metformin, sulphonylureas, insulin, aspirin, clopidogrel, warfarin, statin, ACEI/ARB, β-blocker, D-dimer quartiles