Table 1 Baseline characteristics in patients with CVD events and without CVD events
From: D-dimer as a predictor of cardiovascular outcomes in patients with diabetes mellitus
Characteristic | Total (n = 1976) | CVD events (n = 214) | Non-CVD events (n = 1762) | P value |
|---|---|---|---|---|
Age (years) | 59.6 (49.7–68.2) | 67.4 (51.0–72.4) | 56.9 (48.9–67.6) | 0.009 |
Female | 989 (50.1%) | 102 (47.7%) | 887 (50.3%) | 0.460 |
BMI (kg/m2) | 25.0 (22.9–27.4) | 26.4 (23.3–28.9) | 24.7 (22.4–26.8) | 0.001 |
Daily smoker | 501 (25.4%) | 84 (39.3%) | 417 (23.7%) | < 0.001 |
Total-cholesterol (mmol/L) | 5.3 (4.2–6.3) | 5.4 (4.1–6.2) | 5.2 (4.3–6.3) | 0.262 |
HDL-cholesterol (mmol/L) | 1.04 (0.64–1.29) | 1.04 (0.63–1.29) | 1.06 (0.64–1.30) | 0.371 |
LDL-cholesterol (mmol/L) | 2.93 (1.25–3.96) | 3.87 (2.62–5.42) | 2.21 (1.07–3.24) | 0.001 |
Triglyceride (mmol/L) | 1.80 (0.94–2.46) | 2.13 (1.36–3.93) | 1.60 (0.77–2.36) | 0.001 |
Hypertension | 881 (44.6%) | 127 (59.3%) | 754 (42.8%) | < 0.001 |
HbA1C (%) | 6.2 (5.6–7.3) | 7.6 (6.3–8.8) | 6.1 (5.4–7.0) | 0.001 |
duration of diabetes (years) | 6.3 (4.2–9.4) | 10.2 (5.7–15.1) | 4.6 (3.8–7.9) | 0.001 |
Treatment | ||||
Only diet therapy | 283 (14.3%) | 30 (14.0%) | 253 (14.4%) | 0.893 |
Metformin | 1245 (63.0%) | 103 (48.1%) | 1142 (64.8%) | < 0.001 |
sulphonylureas | 563 (28.5%) | 88 (41.1%) | 475 (27.0%) | < 0.001 |
Insulin | 189 (9.6%) | 20 (9.3%) | 169 (9.8%) | 0.908 |
asipirin | 1116 (56.5%) | 97 (45.3%) | 1019 (57.8%) | < 0.001 |
clopidogrel | 217 (11.0%) | 28 (13.1%) | 189 (10.7%) | 0.298 |
warfarin | 56 (2.8%) | 7 (3.3%) | 49 (2.8%) | 0.683 |
statin | 1460 (73.9%) | 128 (59.8%) | 1332 (75.6%) | < 0.001 |
ACEI/ARB | 699 (35.4%) | 67 (31.3%) | 632 (35.9%) | 0.188 |
β-blocker | 211 (10.7%) | 29 (13.6%) | 182 (10.3%) | 0.150 |
D-dimer (ng/mL) | 203 (121–362) | 287 (140–407) | 197 (118–336) | 0.001 |