Table 4 Performance accuracy comparisons between HEART and HEART2 score predicting MACE outcomes among chest pain patients with previous CIT performed
| Â | HEART | HEART2 | P value | ||
|---|---|---|---|---|---|
Number of patients | Positive MACE | Number of patients | Positive MACE | ||
Low-risk—n (%) | 716 (38.2) | 16 (2.2) | 1040 (55.5) | 32 (3.1) | 0.3021 |
Moderate-risk—n (%) | 1081 (57.7) | 90 (8.3) | 739 (39.4) | 67 (9.1) | 0.6103 |
High-risk—n (%) | 77 (4.1) | 22 (28.6) | 95 (5.1) | 29 (30.5) | 0.8671 |
Patients with Low-risk scores for MACE outcome predictions | |||||
 Sensitivity (%, 95% CI) | 87.5 (80.5–92.7) | 75.0 (66.6–82.2) |  | ||
 Specificity (%, 95% CI) | 40.1 (37.8–42.4) | 57.7 (55.4–60.1) |  | ||
 PPV (%, 95% CI) | 9.7 (8.0–11.5) | 11.5 (9.4–13.9) |  | ||
 NPV (%, 95% CI) | 97.8 (96.4–98.7) | 96.9 (95.797.9) |  | ||
Overall performance accuracy (AUC) | |||||
 Include missing follow-up patients | 0.71 (0.67–0.75) | 0.74 (0.70–0.79) | 0.0082 | ||
 Exclude missing follow-up patients | 0.71 (0.67–0.76) | 0.75 (0.71–0.79) | 0.0037 | ||
 Imputed missing follow-up patients | 0.71 (0.67–0.75) | 0.73 (0.70–0.77) | 0.0266 | ||