Mehdi Akrami et al. [7] | LoDoCO2 [9] | CIRT [22] | COLCOT [8] | CANTOS [11] | STABILITY [15] | SOLID-TIMI [16] | VISTA-16 [14] | COPS [20] | FRANCIS [21] | |
---|---|---|---|---|---|---|---|---|---|---|
Patients (n) | 120/129 | 2762/2760 | 2391/2395 | 2366/2379 | 3344/6717 | 7924/7904 | 6504/6522 | 2572/2573 | 396/399 | 313/311 |
Age (mean) | 56.9/56.9 | 65.8/65.9 | 65.6 /66.0 | 60.6/60.5 | 61.1/61.1 | 65.0/65.0 | 64.0/64.0 | 61.0/60.7 | 59.7/60.0 | 58.5/59.6 |
Male (%) | 86.0/87.0 | 83.5/85.9 | 80.7/81.8 | 80.1/81.6 | 74.1/74.4 | 81.5/81.0 | 74.6/74.5 | 73.1/74.4 | 81.3/77.7 | 73.5/75.9 |
Smokers (%) | 52.0/49.0 | 11.5/12.0 | 11.2/11.3 | 29.9/29.8 | 22.9/43.1 | 19.8/21.0 | 18.9/19.1 | 33.2/33.4 | 32.3/37.3 | 23.3/21.9 |
Hypertension (%) | 52.0/59.0 | 51.4/50.3 | 90.0 /90.6 | 50.1/52.0 | 79.1/79.9 | – | 73.7/73.0 | 74.3/76.8 | 50.8/49.9 | 86.6/88.1 |
Diabetes (%) | 27.0/32.0 | 17.8/18.7 | 33.0/34.4 | 19.5/20.9 | 39.9/40.1 | 33.6/34.0 | 35.0/34.1 | 31.1/31.2 | 18.9/19.8 | 26.8/28.0 |
Previous ACS (%) | – | 84.1/84.6 | 60.7/60.9 | 15.6/16.7 | 87.9/88.2 | 59.1/69.1 | 31.0/31.2 | 29.6/30.2 | 59.0/59.0 | – |
Previous PCI (%) | 16.0/20.0 | 76.0/75.3 | 58.4/59.3 | 16.6/17.0 | 65.6/67.3 | 50.3/50.3 | 23.6/24.2 | 18.6/17.7 | 51.0/50.0 | – |
Previous CABG (%) | 4.0/3.0 | 11.5/14.2 | 42.2/43.1 | 2.9/3.4 | 14.0/14.0 | 33.4/32.8 | – | 7.1/6.3 | 15.0/19.0 | – |
Medication use — no. (%) | ||||||||||
Antiplatelet | 100.0/100.0 | 90.0/80.6 | 87.1/85.8 | 98.6/98.9 | 91.1/92.1 | 100.0/100.0 | 96.4/96.5 | 91.3/91.8 | 99.0/98.0 | 92.7/91.0 |
ACEI or ARB | 100.0/100.0 | 72.2/71.2 | 72.6/72.0 | / | 79.6/79.8 | – | 82.7/82.4 | 82.5/82.3 | 88.0/86.0 | 85.9/81.7 |
Beta-blocker | 100.0/100.0 | 61.3/62.9 | 78.2/79.5 | 89.4/88.3 | – | – | 87.2/87.4 | 83.9/82.9 | 81.0/85.0 | 84.0/84.6 |
Statins | 100.0/100.0 | 93.9/94.0 | 86.1/85.7 | 98.9/99.1 | 91.1/91.1 | 100.0/100.0 | 94.3/94.9 | 98.7/99.0 | 98.0/99.0 | – |
Median lipid levels (IQR) — mg/dl | ||||||||||
LDL cholesterol | – | – | 68.0/68.0 | – | 82.8/82.0 | – | 74.9/74.9 | 105.1/105.0 | – | 61.0/60.3 |
HDL cholesterol | – | – | 41.0/41.0 | – | 44.5/43.7 | 44.4/44.8 | – | 43.2/43.3 | – | – |