Table 6 Summary of LIPID genetic study and previous studies assessing GRS in prediction of secondary cardiovascular risk in patients with documented cardiovascular disease and post-ACS
From: Common genetic variants do not predict recurrent events in coronary heart disease patients
Author | References | Patients | n | Duration of follow-up (years) | CV events | Fatal CV events | Type of GRS | Independent association with CV events |
|---|---|---|---|---|---|---|---|---|
Patel et al. 2012 | [16] | CAD on angiography | 2597 | 2.5 | 358 | 257 | 11 SNPs | No independent association |
Weijmans et al. 2015 | [17] | Symptomatic vascular disease | 5742 | 6.5 | 933 | N/R | 30 SNPs | No independent association |
Labos et al. 2015 | [18] | ACS | 3503 | 1 | 389 | N/R | 30 SNPs | No independent association |
Vaara et al. 2015 | [19] | ACS with coronary angiography | 2090 | 5.5 | 263 | N/R | 47 SNPs 153 SNPs | GRS 47. Adj HR 1.17; 95% CI, 1.01–1.36 p = 0.037. No improvement in C-statistic GRS 153. No association |
Mega et al. 2015 | [8] | Recent ACS (CARE) | 2878 | 4.94 | 330 | N/R | 27 SNPs | HR 1.14 (0.98–1.32) per SD of GRS p = 0.081 |
Mega et al. 2015 | [8] | Recent ACS (PROVE-IT) | 1999 | 2.03 | 22 | N/R | 27 SNPs | HR 1.14 (0.95–1.36) per SD of GRS p = 0.15 |
Christiansen et al. 2017 | [20] | High-risk stable CHD | 879 | 2.8 | N/R | N/R | 45 SNPs | Adj. HR 1.50 (95% CI 1.00–2.25) for all CV events including revascularisation. Risks of CV death and all-cause death unaffected |
Wirtwein et al. 2017 | [21] | CHD on angiography | 1345 | 8.6 | 882 | 114 | 19 SNPs | Inconsistent |
Pereira et al. 2017 | [22] | CHD Southern Europe | 1464 | 4.9 | N/R | 107 | 32 SNPs | No independent association |
Jiang et al. 2020 | [23] | Chinese patients Recent ACS | 1667 | 2 | N/R | N/R | 79 SNPs | HR 1.33 (1.10–1.61) P = 0.003 per SD of GRS; slight increase in discrimination after adjustment for clinical factors |
Current study | CHD, distant ACS | 4932 | > 10 | 554 (2 years) | 898 (10 years) | 27 SNPs (same as Mega et al.) | No independent association No improvement in NRI or C-statistic |