Table 2 Age-adjusted Cox regression hazard model

Screening age-adjusted HR (95% CI)

BMI (per BMI unit)

1.08 (1.04–1.12)

1.09 (1.03–1.15)

1.07 (1.00–1.15)

1.12 (1.01–1.24)

Weight at screening (per kg)

1.02 (1.01–1.03)

1.02 (1.01–1.04)

1.02 (1.00–1.04)

1.03 (1.00–1.06)

Weight gain, 30 years (per kg)

1.02 (1.01–1.03)

1.02 (1.00–1.04)

1.01 (0.99–1.04)

1.03 (0.99–1.07)

Obesity (yes/no)

1.64 (1.08–2.51)

1.83 (1.07–3.12)

1.62 (0.78–3.35)

3.13 (1.31–7.45)

Smoking

Former vs never,

Current vs never

1.09 (0.76–1.54) 1.32 (0.99–1.77)

1.35 (0.88–2.08)

1.54 (1.05–2.25)

1.22 (0.69–2.14) 1.89 (1.18–3.03)

0.70 (0.27–1.82) 2.08 (1.07–4.07)

Sedentary lifestyle (yes/no)

0.84 (0.61–1.16)

0.77 (0.50–1.18)

0.81 (0.47–1.38)

1.10 (0.53–2.30)

Systolic blood pressure (per mm Hg)

1.01 (1.00–1.01)

1.01 (1.00–1.02)

1.01 (1.00–1.02)

1.00 (0.99–1.02)

Diastolic blood pressure (per mm Hg)

1.01 (1.00–1.02)

1.01 (1.00–1.03)

1.01 (0.99–1.02)

1.01 (0.98–1.03)

Pulse pressure (per mm Hg)

1.01 (1.01–1.02)

1.01 (1.00–1.02)

1.02 (1.00–1.03)

1.00 (0.98–1.02)

Heart rate (beats/min)

1.01 (1.00–1.02)

1.01 (1.00–1.02)

1.01 (0.99–1.02)

1.00 (0.97–1.02)

Family history of myocardial infarction, parents (yes/no)

1.33 (0.99–1.79)

1.00 (0.66–1.50)

0.89 (0.52–1.52)

1.03 (0.48–2.23)

Family history of stroke, parents (yes/no)

1.14 (0.86–1.51)

1.23 (0.86–1.76)

1.38 (0.89–2.15)

1.88 (1.00–3.53)

Family history of myocardial infarction, siblings (yes/no)

2.06 (1.33–3.20)

2.59 (1.52–4.42)

1.43 (0.58–3.52)

0.00 (0.00-Inf)

Family history of stroke, siblings (yes/no)

2.02 (1.07–3.80)

2.86 (1.40–5.84)

3.61 (1.58–8.27)

4.35 (1.34–14.09)

Cholesterol (per mmol/L)

1.26 (1.15–1.39)

1.29 (1.15–1.46)

1.22 (1.04–1.43)

1.07 (0.82–1.40)

Atrial fibrillation (yes/no)

-

2.00 (1.19–3.37)

2.25 (1.37–3.69)

2.30 (1.19–4.44)

Diabetes (yes/no)

1.57 (0.50–4.90)

1.19 (0.56–2.54)

1.06 (0.46–2.44)

1.11 (0.40–3.12)

Hypertension (yes/no)

1.40 (1.09–1.80)

1.57 (1.14–2.17)

1.86 (1.23–2.82)

1.77 (0.95–3.31)

Ischemic heart disease (yes/no)

1.54 (1.09–2.18)

1.47 (1.03–2.08)

1.61 (1.06–2.45)

1.49 (0.80–2.75)

Stroke (yes/no)

1.49 (0.21–10.63)

0.60 (0.22–1.62)

0.80 (0.35–1.83)

1.66 (0.74–3.75)

Heart failure (yes/no)

–

1.20 (0.53–2.74)

1.81 (0.96–3.42)

2.69 (1.32–5.48)

Renal failure (yes/no)

–

8.83 (2.79–27.92)

1.33 (0.18–9.55)

0.00 (0.00-Inf)