Fig. 4

The effect of B1 and Tr cells on the plasma levels of immunoglobulin. The plasma IgM, IgG and IgG3 levels were detected by ELISA in the three groups. A The plasma levels of IgM, IgG and IgG3 were compared among DCM, HF and HC groups, and between patients with DCM who were β1-AR autoantibody-positive and h β1-AR autoantibody-negative. There was no significant difference in the levels of IgM, IgG and IgG3 among the three groups, and between the two DCM subgroups. Bars represent the means ± standard deviation. Data were compared using one-way ANOVA or independent sample t test. B–D The correlation between the percentage of B1 cells and the levels of plasma IgM (B), IgG (C) and IgG3 (D) in the DCM subgroup. E–G The correlation between the percentage of Tr cells and the levels of plasma IgM (E), IgG (F) and IgG3 (G) in the DCM subgroup. Neither the percentage of B1 cells nor the percentage of Tr cells was correlated with the levels of IgM, IgG and IgG3. Each point represents an individual in figure B-G. Pearson’s correlation analysis was performed