Fig. 2
Comparison of B1, Tr, naïve and mature B cells among DCM, HF and HC groups. A Representative flow cytometry scatter plots of the percentage of B1 cells in the DCM (n = 27), HF (n = 18) and HC (n = 21) groups. The number in the figure represent the mean of the percentage of B1 cells in CD19+ B cells. B Comparison of the proportion of B1 cells in the peripheral blood among DCM, HF and HC groups. The results showed that the percentage of B1 cells in the DCM group was significantly lower than that in the HF group and HC group. Then, according to the expression of β1-AR autoantibodies, patients with DCM were divided into β1-AR autoantibody-positive and β1-AR autoantibody-negative subgroups, and the proportion of B1 cells was further compared. The results showed that the percentage of B1 cells in patients with DCM who were β1-AR autoantibody-positive was significantly lower than that in β1-AR autoantibody-negative patients. C Representative flow cytometry scatter plots of the percentages of Tr, naïve and mature cells among DCM, HF and HC groups. The number in the figure represent the mean of percentages of Tr, naïve and mature cells in CD19+ B cells. D Compared with the HF and HC groups, the percentage of Tr cells was significantly increased in the DCM group. However, the percentage of Tr cells was similar between β1-AR antibody-positive and β1-AR antibody-negative patients with HF. E, F No significant difference was detected in the percentages of naïve (E) and mature (F) B cells among the three groups. G No significant association was observed between B1 cells and Tr cells in patients with DCM. Each point represents an individual in figure B, D, E, F, G. Data were compared using one-way ANOVA or independent sample t test. *P < 0.05, **P < 0.01