Independent and joint effects of high-sensitivity c-reactive protein and hypoalbuminemia on long-term all-cause mortality among coronary artery disease: a prospective and multicenter cohort study

Table 3 Crude mortality and Cox proportional hazard ratios in different groups

Combined groups		Events, n (%)	All-cause mortality HR (95% Cl), P value
Albumin level	hs-CRP level	Events, n (%)	Univariate	Multivariate^a	P for interaction^a
Non-hypoalbuminemia	Low hs-CRP	17 (2.9%)	Reference	Reference	0.04
	High hs-CRP²	29 (7.9%)	2.73 (1.50–4.97), 0.001	3.03 (1.48–6.19), 0.002
Hypoalbuminemia	Low hs-CRP	12 (8.7%)	3.12 (1.49–6.56), 0.003	2.68 (1.11–6.46), 0.029
	High hs-CRP	39 (13.5%)	4.51 (2.59–7.86), < 0.001	3.79 (1.91–7.52), < 0.001

^aAdjusted for full multivariate: age > 65, gender, smoking, hypertension, acute myocardial infarction, stroke, diabetes mellitus, percutaneous coronary intervention, ejection fraction reduced heart failure, hyperlipidemia, anemia, angiotensin-converting enzyme inhibitor/angiotensin receptor blockers, β-blockers, statins

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