Hyperoxia during extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest is associated with severe circulatory failure and increased mortality

Table 2 Variables associated with in-hospital mortality (univariate analysis)

Variable	OR [95% CI]	p value
Age	1.03 [0.98–1.09]	0.244
Localization of CA (OHCA vs IHCA)	0.88 [0.20–3.54]	0.858
Initial rhythm (VF vs non VF)	0.40 [0.08–1.73]	0.226
SAPS II	1.06 [0.99–1–15]	0.052
No flow duration	0.91 [0.66–1.26]	0.580
Low flow duration	1.06 [1.02–1.11]	0.003
Lactate at ECMO initiation	1.22 [1.06–1.46]	0.005
Mean PaO₂ first 24 h on ECMO	1.03 [1.01–1.06]	< 0.001
Mean PaCO₂ first 24 h on ECMO	0.95 [0.82–1.08]	0.462
Mean BP (first 24 h)	0.84 [0.72–0.98]	0.001
Pulse Pressure (first 24 h)	0.96 [0.90–1.01]	0.129
Total catecholamines (NA + ADRE)	4.51 [1.70–15.68]	0.012
Total Cristalloid	1.67 [0.96–2.89]	0.005
Catheter position (right RA vs other)	2.10 [0.53–9.54]	0.297
Coronarography	0.78 [0.32–5.23]	0.728
PTCA	0.42 [0.10–1.67]	0.217
Packed RBC	1.06 [0.91–1.26]	0.459
FFP	1.14 [0.87–1.49]	0.322

Univariate analysis of variables associated with in-hospital mortality. Data are shown as p values and odds ratio (OR) with 95% confidence interval (CI)
ADRE adrenaline, CA cardiac arrest, ECMO extra-corporeal membrane oxygenation, FFP fresh frozen plasma, IHCA in-hospital cardiac arrest, NA noradrenaline, OHCA out-of-hospital cardiac arrest, PTCA percutaneous transluminal coronary angioplasty, RA radial artery, RBC red blood cells, SAPS simplified acute physiology score, VF ventricular fibrillation

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