Table 3 Hazard ratios (95%CI) for incident ischemic stroke and incident CE in relation to risk factors in MDCS (n = 26,519)

2.01 (1.92–2.10)^c

1.84 (1.77–1.91)^c

0.003

1.84 (1.75–1.93)^c

1.69 (1.62–1.76)^c

0.011

1.56 (1.44–1.69)^c

2.37 (2.20–2.54)^c

 < 0.001

1.35 (1.23–1.48)^c

1.85 (1.70–1.98)^c

 < 0.001

1.18 (1.07–1.30)^b

1.42 (1.31–1.55)^c

0.005

1.09 (0.99–1.20)

1.24 (1.14–1.35)^c

0.040

1.56 (1.42–1.70)^c

1.82 (1.67–1.96)^c

0.010

1.62 (1.48–1.77)^c

1.84 (1.70–1.98)^c

0.038

1.08 (1.06–1.10)^c

1.08 (1.07–1.10)^c

0.716

1.06 (1.03–1.09)^c

1.07 (1.04–1.09)^c

0.898

1.31 (1.26–1.37)^c

1.33 (1.28–1.38)^c

0.618

1.27 (1.22–1.33)^c

1.27 (1.22–1.32)^c

0.973

2.18 (1.88–2.53)^c

2.49 (2.21–2.81)^c

0.168

1.91 (1.64–2.22)^c

2.06 (1.82–2.34)^c

0.443

0.90 (0.86–0.94)^c

0.77 (0.73–0.80)^c

 < 0.001

0.94 (0.90–0.98)^c

0.81 (0.78–0.84)^c

 < 0.001

1.12 (1.08–1.17)^c

1.31 (1.27–1.36)^c

 < 0.001

1.06 (1.02–1.11)^b

1.24 (1.19–1.28)^c

 < 0.001

1.19 (1.14–1.23)^c

1.28 (1.24–1.32)^c

0.004

1.07 (1.03–1.12)^b

1.11 (1.07–1.15)^c

0.228

1.10 (1.06–1.14)^c

1.12 (1.09–1.15)^c

0.342

1.03 (0.99–1.07)

1.02 (0.99–1.06)

0.753

1.17 (1.12–1.21)^c

1.25 (1.21–1.29)^c

0.007

1.07 (1.03–1.12)^b

1.12 (1.08–1.16)^c

0.154

1.05 (1.01–1.10)^b

1.12 (1.08–1.16)^c

0.026

1.00 (0.96–1.04)

1.04 (1.00–1.07)^a

0.206