Table 1 Baseline characteristics according to CC7 (mg/mL) quartiles (Q) in the Argentinean population (ARRA-RACS)
Characteristics | Total n = 980 | Q1 n = 245 | Q2 n = 245 | Q3 n = 245 | Q4 n = 245 | p value |
|---|---|---|---|---|---|---|
CC7 (mg/mL) | 143.6 (112.4–184.7) | 93.4 (78.4–103.3) | 127.7 (120.0–136.2) | 161.3 (152.5–173.1) | 225.3 (202.6–259.4) | < 0.001 |
Age, years | 62.0 (53.0–72.0) | 59.0 (50.0–67.0) | 59.0 (51.0–71.0) | 65.0 (55.0–73.0) | 67.0 (57.0–77.0) | < 0.001 |
Male sex | 586 (59.8) | 157 (64.1) | 142 (58.0) | 152 (62.0) | 135 (55.1) | 0.17 |
Risk markers at baseline | ||||||
hsCRP mg/L | 3.1 (1.4–8.4) | 2.5 (1.1–6.9) | 3.1 (1.4–7.8) | 3.1 (1.3–8.3) | 3.7 (1.8–11.0) | 0.004 |
BNP pg/mL | 78 (36–180) | 63 (32–126) | 61 (32–139) | 91 (41–180) | 111 (51–345) | < 0.001 |
eGFR ml/min/1.73m2 | 82 (64—98) | 85 (71–99) | 83 (69–98) | 81 (62–99) | 78 (57–96) | 0.008 |
Total cholesterol (mmol/L) | 4.7 (4.1–5.5) | 4.8 (4.2–5.5) | 4.9 (4.1–5.6) | 4.7 (4.1–5.5) | 4.6 (3.8–5.4) | 0.017 |
Acute myocardial infarction* | 344 (35.1) | 68 (27.8) | 66 (27.1) | 93 (38.0) | 117 (47.8) | < 0.001 |
TnT release (> 10 ng/L) | 387 (39.5) | 75 (30.6) | 73 (29.9) | 103 (42.0) | 136 (55.5) | < 0.001 |
Risk factors | ||||||
Smoking | 0.024 | |||||
Current smoking | 238 (24.8) | 62 (25.9) | 79 (32.8) | 50 (20.8) | 47 (19.7) | |
Past smoking | 536 (55.8) | 135 (56.5) | 118 (49.0) | 140 (58.1) | 143 (59.8) | |
Hypertension | 632 (64.5) | 147 (60.0) | 153 (62.5) | 162 (66.1) | 170 (69.4) | 0.14 |
Diabetes mellitus type I | 15 (1.6) | 3 (1.2) | 4 (1.6) | 4 (1.7) | 4 (1.7) | 0.98 |
Diabetes mellitus type II | 185 (19.1) | 31 (12.9) | 39 (16.0) | 47 (19.6) | 68 (28.1) | < 0.001 |
Total cholesterol > 6.5 mmol/L | 72 (7.4) | 17 (6.9) | 15 (6.2) | 19 (7.8) | 21 (8.6) | 0.75 |
BMI (kg/m2) | 27.7 (25.3–30.2) | 27.7 (25.4–30.2) | 27.7 (25.7–30.4) | 27.7 (25.0–30.8) | 27.4 (24.9–29.4) | 0.30 |
History of heart disease | ||||||
Angina pectoris | 223 (22.8) | 45 (18.4) | 55 (22.5) | 61 (24.9) | 62 (25.3) | 0.24 |
Myocardial infarction | 93 (9.5) | 24 (9.8) | 19 (7.8) | 18 (7.4) | 32 (13.1) | 0.12 |
Previous CABG | 46 (4.8) | 13 (5.4) | 6 (2.5) | 10 (4.2) | 17 (7.0) | 0.11 |
Previous PCI | 97 (9.9) | 24 (9.8) | 23 (9.4) | 23 (9.4) | 27 (11.0) | 0.92 |
Heart failure | 165 (16.8) | 44 (18.0) | 38 (15.5) | 40 (16.3) | 43 (17.6) | 0.88 |
Treatment prior to admission | ||||||
ACEI/ARB | 407 (41.7) | 86 (35.1) | 96 (39.3) | 109 (44.7) | 116 (47.5) | 0.026 |
Beta-blocker | 252 (26.1) | 66 (27.3) | 59 (24.3) | 62 (25.8) | 65 (27.0) | 0.88 |
Statins | 92 (9.5) | 20 (8.3) | 26 (10.7) | 22 (9.2) | 24 (10.0) | 0.82 |