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Table 4 Unadjusted and adjusted predictors of age of diagnosis with coronary artery disease at Tehran Heart Center from 2005 to 2015

From: Prevalence and trends of coronary artery disease risk factors and their effect on age of diagnosis in patients with established coronary artery disease: Tehran Heart Center (2005–2015)

 

Unit

Unadjusted (95% CI)a

P-value

Adjusted (95% CI)b

P-value

Sex (n = 90,094)

Male (vs. female)

 − 3.12 (− 3.27, − 2.97)

 < 0.001

 − 0.89 (− 1.09, − 0.68)

 < 0.001

Body mass index (n = 65,320)

One SD (4.5 kg/m2)

 − 1.07 (− 1.15, − 0.99)

 < 0.001

 − 1.52 (− 1.60, − 1.43)

 < 0.001

Total Cholesterol (n = 81,363)

One SD (47.3 mg/dL)

 − 0.78 (− 0.85, − 0.71)

 < 0.001

Excludedc

LDL Cholesterol (n = 79,458)

One SD (38.7 mg/dL)

 − 0.64 (− 0.72, − 0.57)

 < 0.001

 − 0.43 (− 0.52, − 0.35)

 < 0.001

HDL Cholesterol (n = 80,899)

One SD (10.6 mg/dL)

1.39 (1.32, 1.47)

 < 0.001

0.71 (0.62, 0.79)

 < 0.001

Triglycerides (n = 81,390)

One SD (96.9 mg/dL)

 − 1.87 (− 1.94, − 1.80)

 < 0.001

 − 1.35 (− 1.45, − 1.26)

 < 0.001

Dyslipidemia (n = 89,899)

Yes (vs. No)

 − 1.65 (− 1.80, − 1.50)

 < 0.001

 − 0.81 (− 1.00, − 0.62)

 < 0.001

Fasting blood sugar (n = 79,822)

One SD (53.3 mg/dL)

0.12 (0.05, 0.19)

0.002

 − 0.32 (− 0.42, − 0.22)

 < 0.001

Diabetes mellitus (n = 89,977)

Yes (vs. No)

1.24 (1.10, 1.39)

 < 0.001

1.05 (0.84, 1.26)

 < 0.001

Hypertension (n = 90,001)

Yes (vs. No)

3.98 (3.84, 4.12)

 < 0.001

3.54 (3.37, 3.71)

 < 0.001

Ever cigarette smoking (n = 89,955)

Yes (vs. No)

 − 4.41 (− 4.55, − 4.26)

 < 0.001

 − 2.76 (− 2.95, − 2.57)

 < 0.001

Ever opium use (n = 87,348)

Yes (vs. No)

 − 4.22 (− 4.43, − 4.02)

 < 0.001

 − 2.20 (− 2.44, − 1.96)

 < 0.001

  1. aAll differences are shown for age at diagnosis by unit in each predictor
  2. bMutually adjusted for all other variables
  3. cTotal cholesterol was not included in the model due to high collinearity with other variables