Fig. 5
From: Structural heart defects associated with ETB mutation, a cause of Hirschsprung disease
sl/sl rat has disproportionally larger reductions in its heart size with respect to its bodyweight. Markedly smaller cardiac-organ/bodyweight ratios were observed in sl/sl rat when comparing to those of control group: whole heart (3.46 mL/g vs. 4.15 mL/g, p value = 0.04), LV (1.77 mL/g vs. 2.16 mL/g, p value = 0.03), RV (1.31 mL/g vs. 1.65 mL/g, p value = 0.04), LA (0.14 mL/g vs. 0.18 mL/g, p value = 0.13), and RA (0.27 mL/g vs. 0.33 mL/g, p value = 0.049). This trend reflected disproportionally larger structural impairment in sl/sl heart with respect to global growth restriction, supporting an intrinsic effect of ETB on heart growth. On the contrary, measurement on aortic arch showed little difference between the two groups: 0.112 mL/g versus 0.118 mL/g, p value = 0.70. RA = Right Atrium; RV = Right Ventricle; LA = Left Atrium; LV = Left Ventricle. *: statistically significant in comparison to ETB−/− group, p ≤ 0.05