Effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on left ventricular remodelling and longitudinal strain: a prospective observational study

Table 6 Univariate correlates of change in indexed LVM, GLS and septal e’ vs. baseline and changes in variables

Variable	Δ indexed LVM		Δ GLS		Δ septal e’
Variable	r	p	r	p	r	p
Age (years)	− 0.06	0.69	0.22	0.11	− 0.11	0.46
Basal glycated haemoglobin	− 0.16	0.25	− 0.19	0.17	0.13	0.36
Δ glycated haemoglobin	− 0.06	0.65	− 0.10	0.46	0.23	0.08
Duration of diabetes (months)	0.01	0.92	− 0.01	0.93	− 0.18	0.21
GF (ml/min/1.73 m²)	0.07	0.62	− 0.26	0.06	0.23	0.12
Δ GF (ml/min/1.73 m²)	− 0.09	0.55	− 0.04	0.78	0.15	0.36
SBP (mmHg)	− 0.18	0.21	0.21	0.13	0.20	0.16
DBP (mmHg)	− 0.12	0.39	− 0.09	0.53	− 0.07	0.63
LV ejection fraction (%)	− 0.04	0.78	0.02	0.90	− 0.03	0.82
Δ Weight (Kg)	0.07	0.63	− 0.09	0.51	0.22	0.13

LVM left ventricular mass, GLS global longitudinal strain, Δ change from baseline to 6-month visit, GF glomerular filtration, SBP systolic blood pressure, DBP diastolic blood pressure, LV left ventricular

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