Fig. 4

Pathway enrichment of TF downstream genes and matching to key signalling pathways of AS or vascular endothelial cell apoptosis. The transcription factors STAT6 (a), ATF3 (b), JUN (c), JUNB (d), MAFF (e), MAFG (f), and STAT1 (g) were enriched in known key signalling pathways related to atherosclerosis. MAFF (e) and MAFG (f) in red letters are novel candidates of TFs involved in vascular endothelial cell apoptosis and were enriched in known key signalling pathways of atherosclerosis. Signalling pathways with bold letters are known key signalling pathways of atherosclerosis. e, f The transcription factors indicated with red letters are novel candidate key TFs involved in vascular endothelial cell apoptosis