Relationship between serum lipid levels and ischemic stroke in patients with atrial fibrillation: a nested case–control study based on the China Atrial Fibrillation Registry

Li, Fei; Du, Xin; He, Liu; Jiang, Chao; Xia, Shijun; Ma, Changsheng; Dong, Jianzeng

doi:10.1186/s12872-021-02237-6

Table 4 Subgroup analysis of the associations of TG level and ischemic stroke

From: Relationship between serum lipid levels and ischemic stroke in patients with atrial fibrillation: a nested case–control study based on the China Atrial Fibrillation Registry

Subgroups	TG (mgmol/dL), median (IQR)	OR	95% CI	P value	P for interaction
BMI					0.223263
Normal (< 24 kg/m²)	18.181.01 (14.220.79, 1.3624.48)	1.0128	0.9769–1.052.38	0.556434^a
Overweight (24–28 kg/m²)	20.521.14 (15.300.85, 1.6229.16)	1.2101	0.994–1.0357	0.13443^a
Obese (BMI ≥ 28 kg/m²)	24.121.34 (18.181.01, 1.7932.22)	0.981.07	0.9130–3.821.06	0.919^a629^a
Age					0.306
< 70	22.68 (16.20, 31.50)	1.01	0.99–1.02	0.547^a
≧70	18.90 (14.49, 25.65)	1.02	1.00–1,03	0.036^a
Smoking					0.21670
Yes	18.361.02 (0.14.9483, 28.801.60)	0.991.02	0.9341–1.062.53	0.822965^a
No	20.521.14 (15.120.84, 1.5628.08)	1.0126	1.003–1.0355	0.03428^a
Drinking					0.73148
Yes	19.891.11 (14.850.83,1.6128.89)	1.0239	0.9763–1.083.07	0.366421^a
No	20.251.13 (15.120.84, 1.5627.90)	1.2101	0.991.00–1.0247	0.04961^a
Atrial fibrillation type					0.76370
Paroxysmal	21.421.19 (15.840.88,1.6229.16)	1.0232	0.995–1.0482	0.130094^a
Non-paroxysmal	18.901.05 (14.760.82, 1.4726.46)	1.0119	0.992–1.0354	0.216181^a
Cardiovascular disease					0.071062
Yes	18.001.00 (13.860.77,1.3724.66)	1.0255	0.9988–1.062.75	0.265132^a
No	21.421.19 (16.020.89, 1.6229.16)	1.0111	0.9987–1.4202	0.339403^a
Metabolic disease					0.462380
Yes	21.601.20 (16.020.89, 1.7631.68)	1.0376	1.007–1.062.91	0.106027^a
No	19.441.08 (0.8214.76, 1.4926.82)	1.018	0.9975–1.0354	0.62990^a
CHA₂DS₂-VASc score					0.29655
Low/medium risk (≤ 1)	21.601.20 (15.30.85, 1.6830.24)	1.014	0.9644–1.062.47	0.804922^b
High risk (≥ 2)	1.0919.62 (15.120.84, 1.5227.27)	1.0125	1.002–1.0352	0.04731^b
HAS-BLED score					0.477544
Low risk (< 3)	21.421.19 (15.300.85, 1.6128.98)	1.0112	0.990–1.0241	0.265311^c
High risk (≥ 3)	18.901.05 (14.580.81, 1.4726.46)	1.3101	0.9881–1.042.13	0.503279^c

BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglyceride
^aAdjusted by BMI, SBP, DBP, CHA₂DS₂-VASc score, and HAS-BLED score, NOAC, LDL and HDL
^bAdjusted by BMI, SBP, DBP, and HAS-BLED score, NOAC, LDL and HDL
^cAdjusted by BMI, SBP, DBP, and CHA₂DS₂-VASc score, NOAC, LDL and HDL

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